2020 POSTERS

COMPLEMENTARY AND ALTERNATIVE THERAPIES

ID: CAM01
Multiple Sclerosis Imbalance: Visual Rehabilitation
Marcia Baptista Dias,1 Alice Estevo Dias2
1Rehabilitation and 2Scientific Research, Brazilian Association of Multiple Sclerosis, Sao Paulo, Brazil
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ID: CAM02
Acupuncture and Electromagnet
Alice Estevo Dias,1 Teresa Cristina Vieira2
1Scientific Research and 2Rehabilitation, Brazilian Association of Multiple Sclerosis, Sao Paulo, Brazil
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ID: CAM03
The Effects of Reflexology in People with Multiple Sclerosis
Alice Estevo Dias,1 Evanda Soares Oliveira2
1Scientific Research and 2Rehabilitation, Brazilian Association of Multiple Sclerosis, Sao Paulo, Brazil
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ID: CAM04
The Effects of CBD:THC Tincture Oil in Reducing Symptoms and Overall Symptom Management Medication Dosages, in Persons with Multiple Sclerosis
Aryn Sieber,1 Kristine Werner,2 Karen Carera,3 Ben Thrower,4 Jacqueline Rosenthal4
1CannaCauses Foundation, Los Angeles, CA; 2Smyrna, GA; 3Brookhaven, GA; 4Andrew C. Carlos MS Institute, Shepherd Center, Atlanta, GA
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Time: 7:00 – 7:40 pm ET | Meeting Password: 3Mh55F

ID: CAM05
Challenges and Opportunities in Progressive Multiple Sclerosis Trials: Lessons from Lipoic Acid

Carin S. Waslo,1,2 M. Mateo Paz Soldan,3,4 Mark S. Freedman,5 Pavle Repovic,6 Andrew J. Solomon,7 John R. Rinker,8 Mitchell T. Wallin,9 Jodie K. Haselkorn,10 Rebecca I. Spain11
1Neurology, VA Portland Health Care System, Portland, OR; 2Neurology, Oregon Health & Science University, Portland, OR; 3Neurology, University of Utah, Salt Lake City, UT; 4Neurology, VA Salt Lake City HCS, Salt Lake City, UT; 5University of Ottawa and the Ottawa Hospital Research Institute, Ottawa, ON, Canada; 6Multiple Sclerosis Center, Swedish Neuroscience Institute, Seattle, WA; 7Neurological Sciences, University of Vermont College of Medicine, Burlington, VT; 8Neurology, University of Alabama at Birmingham,
Birmingham, AL; 9Washington, DC VAMC, MS Center of Excellence, Washington, DC; 10Department of Epidemiology, University of Washington, Seattle, WA; 11Oregon Health & Science University, Portland, OR

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ID: CAM06
Exercise in Medicine: A Complementary Exercise Promotion Approach Within Comprehensive Multiple Sclerosis Care
Emma V. Richardson,1 Elizabeth Barstow,2 Matthew Fifolt,3 Robert W. Motl1
1Department of Physical Therapy, 2Department of Occupational Therapy, and 3Department of Health Care Organization & Policy, University of Alabama at Birmingham, Birmingham, AL
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ID: CAM07
Changes in Dietary Habits of Individuals Living with Multiple Sclerosis Enrolled in a Day Wellness Program
Zoe Edwards,1 Brian Hutchinson,2 Tiffany Malone1
1Multiple Sclerosis Achievement Center, Dignity Health, Citrus Heights, CA; 2Multiple Sclerosis Achievement Center, Dignity Health, Sacramento, CA
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CASE REPORT AND CASE SERIES

ID: CRS01
Seasonal Variation and Other Observations in Myelin Oligodendrocyte Glycoprotein (MOG) Antibody– Associated Disease

Allison N. Block, Ahmed Z. Obeidat
Neurology, Medical College of Wisconsin, Milwaukee, WI

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Time: 7:30 – 8:10 pm ET

ID: CRS02
Multiple Surgeries and Misdiagnosis Before Multiple Sclerosis Diagnosis: A Case Report
Angel Lopez,1 Joanie Figueroa-Amaro,2 Astrid Diaz,1 Viviana Martinez,1 Ivonne Vicente,1 Angel Chinea1
1San Juan Multiple Sclerosis Center, Guaynabo, PR; 2Medicine, San Juan Bautista School of Medicine, Caguas, PR
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ID: CRS03
Head Trauma as Onset for Multiple Sclerosis Diagnosis: A Case Report

Astrid Diaz, Viviana Martinez, Ivonne Vicente, Cristina M. Rubi, Angel Lopez, Angel Chinea
San Juan Multiple Sclerosis Center, Guaynabo, PR

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ID: CRS04
Team Approach Yields Surprising Functional Progress and Quality-of-Life Changes in a Challenging Case of Neuromyelitis Optica
Clare T. Hartigan,1 Christopher Wells2
1Multiple Sclerosis Outpatient Rehabilitation, Shepherd Center, Atlanta, GA; 2Multiple Sclerosis Wellness Program, Shepherd Center, Atlanta, GA
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Time: 7:00 – 7:40 pm ET | Meeting Password: 3Wgty4

ID: CRS05
Differential Diagnosis and Treatment of Tumefactive Demyelination in a Teenaged Girl
Gillian R. Paton, Sarah Hopkins
Division of Neurology, Multiple Sclerosis and Neuroinflammatory Disorders, Children’s Hospital of Philadelphia, Philadelphia, PA
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ID: CRS06
A Long-Standing Case of Recurrent Transverse Myelitis Due to Myelin Oligodendrocyte Glycoprotein (MOG)–IgG Antibody Mimicking Multiple Sclerosis
Gina S. Perez, Peggy J. Wisdom, Nidhiben Anadani
Neurology, University of Oklahoma Health Sciences Center, Oklahoma City, OK
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Time: 7:00 – 7:40 pm ET

ID: CRS07
Case Report of Severe Multiple Sclerosis Relapse Due to B-Cell Reconstitution Post Alemtuzumab
Jennifer Chester,1 Tyler Kaplan2
1Kansas City Multiple Sclerosis Center, College Park Specialty Center, Overland Park, KS; 2Neuro-immunology, Rush University Medical Center and University of Utah, Chicago, IL
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Time: 7:30 – 8:10 pm ET | Meeting Password: 6Au0i6

ID: CRS08
Demographics, Clinical Characteristics, and Outcomes of Myelin Oligodendrocyte Glycoprotein (MOG) Antibody Disease Followed Up at Washington University in St. Louis
John R. Ciotti, Anne Cross, Salim Chahin
Washington University in St. Louis, St. Louis, MO
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ID: CRS09
A Fatal Case of Alemtuzumab-Induced Immune Thrombocytopenic Purpura in a Patient with Relapsing Multiple Sclerosis
Leila Saadatpour, Rebecca Romero
Neurology, University of Texas Health Science Center at San Antonio, San Antonio, TX
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Meeting Password: 0VuS52

ID: CRS10
Colitis Associated with Teriflunomide
Neda Zarghami Esfahani,1 Gloria von Geldern,1 Meghan C. Romba,1 Dhavan Parikh,2 Annette Wundes1
1Neurology, University of Washington, Seattle, WA; 2Gastroenterology, Everett Clinic, Everett, WA
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ID: CRS11
Remarkable Recovery of Fulminant Multiple Sclerosis After Treatment Induction with Cyclophosphamide
Nicola Carlisle,1 Sam I. Hooshmand,1 Michelle Maynard,2 Ahmed Z. Obeidat3
1Neurology, Medical College of Wisconsin and Affiliated Hospitals, Milwaukee, WI; 2Neurosciences, Froedtert and the Medical College of Wisconsin, Milwaukee, WI; 3Neurology, Medical College of Wisconsin, Milwaukee, WI
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ID: CRS12
Neurofibromatosis Type 1 and Multiple Sclerosis in the Same Patient
Sargon Bet-Shlimon, Annette Wundes, Gloria von Geldern
Neurology, University of Washington, Seattle, WA
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Time: 7:45 pm – 8:30 pm ET | Meeting Password: SGpVdDlHQVEwNEFJT2FMeDl2OFVzUT09

ID: CRS13
Successful Use of Immunotherapy for Osmotic Demyelination Syndrome
Wijdan Rai,1 Stephen Kolb2
1Neurology, Ohio State University, Columbus, OH; 2Ohio State University, Columbus, OH
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Time: 7:00 pm – 7:40 pm ET | Meeting Password: 298147

DISEASE MODIFYING THERAPIES PART 1

ID: DXT01
Maintenance of Working Status and Work Productivity in Persons with Multiple Sclerosis Treated with Dimethyl Fumarate: A 5-Year Analysis of the North American Research Committee on Multiple Sclerosis (NARCOMS) Registry

Amber Salter,1 Samantha Lancia,1 Gary Cutter,2 Robert J. Fox,3 Ruth Ann Marrie,4 Jason P. Mendoza,5 James B. Lewin5
1Biostatistics, Washington University School in St. Louis, School of Medicine, St. Louis, MO; 2Biostatistics, University of Alabama at Birmingham, Birmingham, AL; 3Cleveland Clinic, Cleveland, OH; 4Health Sciences Centre Winnipeg, University of Manitoba, Winnipeg, MB, Canada; 5Biogen, Cambridge, MA

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ID: DXT02
Early Effect of Ofatumumab on B-Cell Counts and Magnetic Resonance Imaging Activity in Relapsing Multiple Sclerosis Patients: Results from the APLIOS Study
Amit Bar-Or,1 Edward J. Fox,2 Alexandra Goodyear,3 Inga Ludwig,4 Morten Bagger,4 Dieter A. Haering,4 Harald Kropshofer,4 Martin Merschhemke,4 Heinz Wiendl5
1Center for Neuroinflammation and Experimental Therapeutics and Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA; 2Central Texas Neurology Consultants and Dell Medical School, The University of Texas at Austin, Round Rock, TX; 3Novartis Pharmaceuticals Corporation, East Hanover, NJ; 4Novartis Pharma AG, Basel, Switzerland; 5Department of Neurology, University of Münster, Münster, Germany
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ID: DXT03
Analyses of the Effect of Disease Duration on the Efficacy and Safety of Siponimod in Patients with Active Secondary Progressive Multiple Sclerosis from the EXPAND Study

Amit Bar-Or,1 Stanley L. Cohan,2 Patricia K. Coyle,3 Fred D. Lublin,4 Xiangyi Meng,5 Wendy Su,5 Bruce A.C. Cree,6
1Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA; 2Providence Multiple Sclerosis Center, Providence Brain Institute, Portland, OR; 3Stony Brook University, Stony Brook, NY; 4Icahn School of Medicine at Mount Sinai, New York, NY; 5Novartis Pharmaceuticals Corporation, East Hanover, NJ; 6Department of Neurology, UCSF Weill Institute for Neurosciences, University of California San Francisco, San Francisco, CA

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ID: DXT04
Siponimod First-Dose Effects in Patients with Secondary Progressive Multiple Sclerosis Receiving Concomitant Selective Serotonin Reuptake Inhibitor Therapy

Amit Bar-Or,1 Bruce A.C. Cree,2 Le H. Hua,3 Amos Katz,4 Derrick Robertson,5 Brandon Brown,6 Desiree Dunlop,6 Xiangyi Meng,6 Wendy Su6
1Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA; 2Department of Neurology, UCSF Weill Institute for Neurosciences, University of California San Francisco, San Francisco, CA; 3Lou Ruvo Center for Brain Health, Las Vegas, NV; 4Linda Cardinale MS Center, Freehold, NJ; 5University of South Florida, Multiple Sclerosis Center, Tampa, FL; 6Novartis Pharmaceuticals Corporation, East Hanover, NJ

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ID: DXT05
Efficacy of Diroximel Fumarate in Highly Active Relapsing-Remitting Multiple Sclerosis: Interim Results from the Phase 3 EVOLVE-MS-1 Study

Annette Wundes,1 Enrique Alvarez,2 Mark S. Freedman,3 Oksana Mokliatchouk,4 Hailu Chen,4 Shivani Kapadia,4 Jordan Messer,4 Robert T. Naismith5
1Department of Neurology, University of Washington Medical Center, Seattle, WA; 2Department of Neurology, University of Colorado School of Medicine, Aurora, CO; 3University of Ottawa and the Ottawa Hospital Research Institute, Ottawa, ON, Canada; 4Biogen, Cambridge, MA; 5Washington University School of Medicine, St. Louis, MO

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ID: DXT06
Real-World Effectiveness of Peginterferon Beta1a Versus Interferon Beta-1a and Glatiramer Acetate in US Multiple Sclerosis Patients
Anthony T. Reder,1 Nancy Arndt,1 Caroline Geremakis,2 Jason P. Mendoza,2 Ray Su,2 Charles Makin,2 Megan C. Vignos,2 Robin L. Avila2
1University of Chicago Neurology, Chicago, IL; 2Biogen, Cambridge, MA
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ID: DXT07
Injection Site Reactions and Risk of Discontinuation Among New and Experienced Peginterferon Beta-1a Users in the Plegridy Observational Program
Ayo Adeyemi,1 Nicole Tsao,1 Arman Altincatal,1 Maria L. Naylor,1 Marco Salvetti,2 Sibyl Wray,3 Gereon Nelles,4 Charles Makin1
1Biogen, Cambridge, MA; 2Sapienza University, S. Andrea Hospital, Rome, Italy; 3Hope Neurology, Knoxville, TN; 4Neurology, NeuroMed Campus Hohenlind, Cologne, Germany
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ID: DXT08
Post Hoc Analysis of Efficacy of Cladribine Tablets in Patients with Relapsing-Remitting Multiple Sclerosis Diagnosed Within 3 or 4 Years Prior to the CLARITY Study

Barry Singer,1 Gavin Giovannoni,2 Nicola De Stefano,3 Matt Mandel,4 Yann Hyvert,5 Julie Aldridge,4 Andrew Galazka,6 Caroline Lemieux,7 Mark S. Freedman8
1Missouri Baptist Medical Center, St Louis, MO; 2Blizard Institute of Cell and Molecular Science, London, United Kingdom; 3University of Siena, Siena, Italy; 4EMD Serono Inc, Billerica, MA; 5Merck KGaA, Darmstadt, Germany; 6Merck, Aubonne, Switzerland; 7EMD Serono Inc., Mississauga, ON, Canada; 8University of Ottawa and the Ottawa Hospital Research Institute, Ottawa, ON, Canada

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ID: DXT09
Exploration of Factors Which Influence Treatment Decisions of Patients with Multiple Sclerosis
Belinda Bardsley,1 John Haynes,2 Edith Cinc,1 Elise Heriot,1 K.-J. Lazarus,1 Melanie McMurtrie,1 Richard A.L. Macdonell3
1Neurology, Austin Health, Heidelberg, VIC, Australia; 2Faculty of Pharmacy and Pharmaceutical Sciences, Monash University, Parkville, Parkville, VIC, Australia; 3Austin Health and Florey Institute of Neuroscience and Mental Health, Melbourne, VIC, Australia
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ID: DXT10
Siponimod Affects Disability Progression in Patients with Secondary Progressive Multiple Sclerosis Independent of Relapse Activity: Results from the Phase 3 EXPAND Study

Bruce A.C. Cree,1 Robert J. Fox,2 Gavin Giovannoni,3 Patrick Vermersch,4 Amit Bar-Or,5 Ralf Gold,6 Nicolas Rouyrre,7 Goeril Karlsson,7 Frank Dahlke,7 Ludwig Kappos8
1Department of Neurology, UCSF Weill Institute for Neurosciences, University of California San Francisco, San Francisco, CA; 2Mellen Center for Multiple Sclerosis, Cleveland Clinic, Cleveland, OH; 3Queen Mary University of London, Blizard Institute, Barts and the London School of Medicine and Dentistry, London, United Kingdom; 4Department of Neurology, University of Lille, CHU Lille, Lille, France; 5Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA; 6Department of Neurology, St. Josef-Hospital/Ruhr-University Bochum, Bochum, Germany; 7Novartis Pharma AG, Basel, Switzerland; 8Departments of Medicine, Clinical Research, Biomedicine, and Biomedical Engineering, Neurologic Clinic and Policlinic, University Hospital Basel, University of Basel, Basel, Switzerland

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ID: DXT11
The Implications of Suboptimal Treatment Outcomes with Disease-Modifying Drugs in Employees with Multiple Sclerosis

Carrie M. Hersh,1 Richard A. Brook,2 Ian A. Beren,3 Nicholas J. Rohrbacker,3 Lori Lebson,4 Christian Henke,5 Amy L. Phillips6
1Lou Ruvo Center for Brain Health, Cleveland Clinic, Las Vegas, NV; 2Better Health Worldwide, Inc, Newfoundland, NJ; 3The HCMS Group, LLC, Pittsburgh, PA; 4EMD Serono, Inc, Rockland, MA; 5Merck KGaA, Darmstadt, Germany; 6Health Economics & Outcomes Research, EMD Serono, Inc, Rockland, MA

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ID: DXT12
Real-World Effectiveness of Peginterferon Beta- 1a Versus Teriflunomide in US Multiple Sclerosis Patients
Cortnee Roman,1 Caroline Geremakis,2 Jason P. Mendoza,2 Ray Su,2 Charles Makin,2 Megan C. Vignos,2 Robin L. Avila2
1Rocky Mountain Multiple Sclerosis Clinic, Salt Lake City, UT; 2Biogen, Cambridge, MA
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ID: DXT13
Disease-Modifying Therapies: How Confident Are We That We Understand Their Risk?
Cortnee Roman,1 Christen Kutz,2 Timothy West1
1Rocky Mountain Multiple Sclerosis Clinic, Salt Lake City, UT; 2Colorado Springs Neurological Associates, Colorado Springs, CO
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ID: DXT14
Long-Term Safety and Efficacy of Eculizumab in Neuromyelitis Optica Spectrum Disorder
Dean Wingerchuk,1 Sean J. Pittock,2 Achim Berthele,3 Kazuo Fujihara,4,5,6 Ho Jin Kim,7 Michael Levy,8,9 Jacqueline Palace,10 Ichiro Nakashima,4,11 Murat Terzi,12 Natalia Totolyan,13 Shanthi Viswanathan,14 Kai-Chen Wang,15,16 Kerstin Allen,17 Kenji P. Fujita,17 Marcus Yountz,17 Roisin Armstrong17
1Mayo Clinic, Scottsdale, AZ; 2Mayo Clinic, Rochester, MN; 3Technical University of Munich, Munich, Germany; 4Tohoku University, Sendai, Japan; 5Fukushima Medical University, Fukushima City, Japan; 6Southern TOHOKU Research Institute for Neuroscience (STRINS), Koriyama, Japan; 7National Cancer Center, Goyang, Korea, Republic of (South); 8Massachusetts General Hospital and Harvard Medical School, Boston, MA; 9Johns Hopkins University, Baltimore, MD; 10John Radcliffe Hospital, Oxford, United Kingdom; 11Tohoku Medical and Pharmaceutical University, Sendai, Japan; 12Ondokuz Mayis University, Samsun, Turkey; 13First Pavlov State Medical University of St Petersburg, St Petersburg, Russian Federation; 14Kuala Lumpur Hospital, Kuala Lumpur, Malaysia; 15Cheng-Hsin General Hospital, Taipei, Taiwan; 16National Yang Ming University, Taipei, Taiwan; 17Alexion Pharmaceuticals, Boston, MA
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ID: DXT15
Inebilizumab Reduces Neuromyelitis Optica Spectrum Disorder Disability Worsening: Outcomes and Long-Term Follow-up Data from the N-MOmentum Trial
Dean Wingerchuk,1 Romain Marignier,2 Jeffrey L. Bennett,3 Ho Jin Kim,4 Brian Weinshenker,5 Sean J. Pittock,6 Kazuo Fujihara,7 Friedemann Paul,8 Gary Cutter,9 Ari Green,10 Orhan Aktas,11 Hans-Peter Hartung,12 Fred D. Lublin,13 Maureen A. Mealy,14 Jorn Drappa,14 Gerard Barron,14 Soraya Madani,14 Dewei She,14 Daniel Cimbora,14 William Rees,14 John N. Ratchford,14 Eliezer Katz,14 Bruce A.C. Cree15
1Mayo Clinic, Scottsdale, AZ; 2Lyon University Hospital, Lyon, France; 3School of Medicine, University of Colorado, Aurora, CO; 4Research Institute and Hospital of National Cancer Center, Goyang, Korea, Republic of (South); 5Neurology, Mayo Clinic, Rochester, MN; 6Mayo Clinic, Rochester, MN; 7Department of Multiple Sclerosis Therapeutics, Southern Tohoku Research Institute for Neuroscience (STRINS), Koriyama, Japan; 8Experimental and Clinical Research Center, Max Delbrueck Center for Molecular Medicine and Charite – Universitatsmedizin Berlin, Berlin, Germany; 9Biostatistics, University of Alabama at Birmingham, Birmingham, AL; 10Department of Neurology and Department of Ophthalmology, UCSF Weill Institute for Neurosciences, San Francisco, CA; 11Medical Faculty, Heinrich-Heine-University, Dusseldorf, Germany; 12Department of Neurology, UKD, Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany; 13Icahn School of Medicine at Mount Sinai, New York, NY; 14Viela Bio, Gaithersburg, MD; 15Department of Neurology and Department of Ophthalmology, UCSF Weill Institute for Neurosciences, University of California San Francisco, San Francisco, CA
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ID: DXT16
Effectiveness of Delayed-Release Dimethyl Fumarate Relative to Duration of Prior Glatiramer Acetate in Patients Enrolled in the RESPOND Study
Derrick Robertson,1 Pavle Repovic,2 Stanley L. Cohan,3 Yang Mao-Draayer,4 Ray Su,5 James B. Lewin,5 Jenna Borowski6
1USF Multiple Sclerosis Center, Tampa, FL; 2Multiple Sclerosis Center, Swedish Neuroscience Institute, Seattle, WA; 3Providence Multiple Sclerosis Center, Providence Brain Institute, Portland, OR; 4University of Michigan Medical School, Ann Arbor, MI; 5Biogen, Cambridge, MA; 6Biogen, Weston, MA
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ID: DXT17
Long-term Follow-up Results from the Phase 2 Multicenter Study of Ublituximab (UTX), a Novel Glycoengineered Anti-CD20 Monoclonal Antibody, in Patients with Relapsing Multiple Sclerosis
Edward J. Fox,1 Sibyl Wray,2 Richard Shubin,3 Amy Lovett-Racke,4 Deren Huang,5 Ann D. Bass,6 Michael S. Weiss,7 Sean Power,7 Jenna Bosco,7 Koby Mok7
1Central Texas Neurology Consultants and Dell Medical School, The University of Texas at Austin, Round Rock, TX; 2Hope Neurology, Knoxville, TN; 3Arcadia Neurology Center, Arcadia, CA; 4Ohio State University, Columbus, OH; 5Mount Carmel Neurology, Westerville, OH; 6Neurology Center of San Antonio, San Antonio, TX; 7TG Therapeutics, New York, NY
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ID: DXT18
Adherence and Compliance with Subcutaneous Administration of Ofatumumab in Relapsing Multiple Sclerosis
Edward Fox,1 Lori Mayer,2 Angela Aungst,3 Alexandra Goodyear,4 Cecile Kerloeguen,5 Linda Mancione,4 Nicola Rennie,5 Dee Stoneman,5 Martin Zalesak,5 Marina Ziehn,4 Derrick Robertson,6 Jeffrey A. Cohen7
1Central Texas Neurology Consultants, Multiple Sclerosis Clinic of Central Texas, Round Rock, TX; 2MS Clinic of Central Texas, Central Texas Neurology Consultants, Round Rock, TX; 3Multiple Sclerosis Division Department of Neurology University of South Florida, Florida, FL; 4Novartis Pharmaceuticals Corporation, East Hanover, NJ; 5Novartis Pharma AG, Basel, Switzerland; 6College of Medicine, Neurology, University of South Florida, Tampa, FL; 7Department of Neurology, Mellen MS Center, Neurological Institute, Cleveland Clinic, Cleveland, OH
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ID: DXT20
Glatiramer Acetate (GA) Produced by Mapi Pharma Is Equivalent to Commercially Available GA Preparations
Susanna Tchilibon, Nadav Bleich Kimelman, Shai Rubnov, Laura Popper, Uri Danon, Ehud Marom
Mapi Pharma Ltd, Ness Ziona, Israel
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ID: DXT22
Characterization of Incidence and Time-toRecovery from Grade 3/4 Lymphopenia Lasting ≥6 Months in Patients with Multiple Sclerosis Treated with Cladribine Tablets
Gabriel Pardo,1 Kottil Rammohan,2 Thomas P. Leist,3 Julie Aldridge,4 Ciara Rossier,5 Axel Nolting,6 Matt Mandel,4 Andrew Galazka,5 Daniel Jones,7 Gavin Giovannoni8
1Oklahoma Medical Research Foundation, Oklahoma City, OK; 2Department of Neurology, Multiple Sclerosis Center, University of Miami, Miami, FL; 3Jefferson University Hospital, Philadelphia, PA; 4EMD Serono Inc, Billerica, MA; 5Merck, Aubonne, Switzerland; 6Merck KGaA, Darmstadt, Germany; 7EMD Serono Inc, Rockland, MA; 8Blizard Institute of Cell and Molecular Science, London, United Kingdom
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ID: DXT23
Disease-Modifying Therapy Landscape: An Evaluation of Cost and Care
Gail Bridges,1 Douglas Mager,2 Mary Dorholt,2 Rochelle Henderson2
1Accredo, Memphis, TN; 2Express Scripts Inc, St. Louis, MO
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ID: DXT24
Two Expanded Disability Status Scale Subscales Evaluated in Patients with Relapsing-Remitting or Secondary Progressive Multiple Sclerosis
Gary Cutter,1 Xiangyi Meng,2 Jamie L. Weiss,2 Ralph H.B. Benedict,3 Stanley L. Cohan,4 Bruce A.C. Cree,5 Wendy Su,2 Florian P. Thomas6,7
1School of Public Health, University of Alabama, Birmingham, AL; 2Novartis Pharmaceuticals Corporation, East Hanover, NJ; 3University at Buffalo, State University of New York, Buffalo, NY; 4Providence Multiple Sclerosis Center, Providence Brain Institute, Portland, OR; 5Department of Neurology, UCSF Weill Institute for Neurosciences, University of California San Francisco, San Francisco, CA; 6Hackensack Meridian School of Medicine, Nutley, NJ; 7Department of Neurology, Multiple Sclerosis Center, Hackensack University Medical Center, Hackensack, NJ
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ID: DXT26
Long-Term Disease Stability Assessed by the Expanded Disability Status Scale in Patients Treated with Cladribine Tablets in the CLARITY and CLARITY Extension Studies
Gavin Giovannoni,1 Giancarlo Comi,2 Kottil Rammohan,3 Peter Rieckmann,4 Patrick Vermersch,5 Fernando Dangond,6 Birgit Keller,7 Dominic Jack7
1Queen Mary University of London, London, United Kingdom; 2Department of Neurology and Institute of Experimental Neurology, Universita Vita-Salute San Raffaele, Milan, Italy; 3Department of Neurology, Multiple Sclerosis Center, University of Miami, Miami, FL; 4Department of Neurology, Medical Park Loipl, and University of Erlangen, Erlangen, Germany; 5University of Lille, Lille, France; 6EMD Serono Inc, Billerica, MA; 7Merck KGaA, Darmstadt, Germany
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ID: DXT27
Integrated Lymphopenia Analysis in Younger and Older Patients with Multiple Sclerosis Treated with Cladribine Tablets
Gavin Giovannoni,1 Patricia K. Coyle,2 Patrick Vermersch,3 Bryan Walker,4 Julie Aldridge,5 Axel Nolting,6 Sana Syed,5 Andrew Galazka,7 Daniel Jones,8 Thomas P. Leist9
1Queen Mary University of London, London, United Kingdom; 2Stony Brook University, Stony Brook, NY; 3University of Lille, Lille, France; 4Neurological Department, Duke University School of Medicine, Durham, NC; 5EMD Serono Inc, Billerica, MA; 6Merck KGaA, Darmstadt, Germany; 7Merck, Aubonne, Switzerland; 8EMD Serono Inc, Rockland, MA; 9Jefferson University Hospital, Philadelphia, PA
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ID: DXT28
Effectiveness of Cladribine Tablets in Patients with Relapsing-Remitting Multiple Sclerosis with Baseline Expanded Disability Status Scale Score ≥3.5 or ≤3.0 in CLARITY
Giancarlo Comi,1 Gabriel Pardo,2 Fernando Dangond,3 Julie Aldridge,3 Caroline Lemieux,4 Kottil Rammohan5
1Department of Neurology and Institute of Experimental Neurology, Universita Vita-Salute San Raffaele, Milan, Italy; 2Oklahoma Medical Research Foundation, Oklahoma City, OK; 3EMD Serono Inc, Billerica, MA; 4EMD Serono Inc, Mississauga, ON, Canada; 5Department of Neurology, Multiple Sclerosis Center, University of Miami, Miami, FL
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ID: DXT29
ACAPELLA: Real-World Experience with Ocrelizumab: An Observational Study Evaluating Safety in Patients with Relapsing and Progressive Multiple Sclerosis, Year 3 Data
Hannah M Geils, India C. Stribling, Joshua D. Katz, Ellen S. Lathi
The Elliot Lewis Center for Multiple Sclerosis Care, Wellesley, MA
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ID: DXT30
ACAPELLA: Hypogammaglobulinemia and JC Virus Status in Ocrelizumab-Treated Patients, Year 2 Data
Hannah M. Geils, India C. Stribling, Joshua D. Katz, Ellen S. Lathi
The Elliot Lewis Center for Multiple Sclerosis Care, Wellesley, MA
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ID: DXT31
Impact of Eculizumab on Hospitalization Rates and Relapse Treatment in Patients with Neuromyelitis Optica Spectrum Disorder: Phase 3 PREVENT Study
Ho Jin Kim,1 Sean J. Pittock,2 Achim Berthele,3 Kazuo Fujihara,4,5,6 Michael Levy,7,8 Jacqueline Palace,9 Ichiro Nakashima,5,10 Murat Terzi,11 Natalia Totolyan,12 Shanthi Viswanathan,13 Kai-Chen Wang,14,15 Amy Pace,16 Kenji P. Fujita,16 Marcus Yountz,16 Roisin Armstrong,16 Dean Wingerchuk17
1National Cancer Center, Goyang, Korea, Republic of (South); 2Mayo Clinic, Rochester, MN; 3Technical University of Munich, Munich, Germany; 4Southern TOHOKU Research Institute for Neuroscience (STRINS), Koriyama, Japan; 5Tohoku University, Sendai, Japan; 6Fukushima Medical University, Fukushima City, Japan; 7Massachusetts General Hospital and Harvard Medical School, Boston, MA; 8Johns Hopkins University, Baltimore, MD; 9John Radcliffe Hospital, Oxford, United Kingdom; 10Tohoku Medical and Pharmaceutical University, Sendai, Japan; 11Ondokuz Mayis University, Samsun, Turkey; 12First Pavlov State Medical University of St. Petersburg, St. Petersburg, Russian Federation; 13Kuala Lumpur Hospital, Kuala Lumpur, Malaysia; 14National Yang Ming University, Taipei, Taiwan; 15Cheng-Hsin General Hospital, Taipei, Taiwan; 16Alexion Pharmaceuticals, Boston, MA; 17Mayo Clinic, Scottsdale, AZ
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ID: DXT33
ACAPELLA: B-Cell Reconstitution in OcrelizumabTreated Patients
India C. Stribling, Hannah M. Geils, Joshua D. Katz, Ellen S. Lathi
The Elliot Lewis Center for Multiple Sclerosis Care, Wellesley, MA
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ID: DXT34
Revealing the Immune Cell Subtype Reconstitution Profile in Cladribine-Treated Patients at the 96-Week Timepoint (CLARITY) Using Deconvolution Algorithms

Irina Kalatskaya,1 Gavin Giovannoni,2,3 Thomas P. Leist,4 Per Soelberg-Sorensen,5 Ursula Boschert,6 Julie DeMartino,1 Alex Rolfe1
1EMD Serono, Inc, Billerica, MA; 2Blizard Institute of Cell and Molecular Science, London, United Kingdom; 3Queen Mary University of London, London, United Kingdom; 4Jefferson University Hospital, Philadelphia, PA; 5Department of Neurology, Danish MS Center, University of Copenhagen, Copenhagen, Denmark; 6Merck Serono S.A., Eysins, Switzerland

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ID: DXT35
Real-World Experience with Ocrelizumab: A Safety Analysis
Jamie Bolling,1 Ryan McNiff,2 Aaron Carlson,1 Carlos Vervloet Sollero,1 Tirisham V. Gyang1
1Neurology, University of Florida, Gainesville, FL; 2UF Health, University of Florida, Gainesville, FL
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ID: DXT36
Effect of Evobrutinib, a Bruton’s Tyrosine Kinase Inhibitor, on Immune Cell and Immunoglobulin Levels over 48 Weeks in a Phase 2 Study in Relapsing Multiple Sclerosis
Xavier Montalban,1,2 Jamie Shaw,3 Sana Syed,3 Fernando Dangond,3 Emily C. Martin,3 Roland Grenningloh,3 Martin S. Weber,4 on behalf of the Evobrutinib Phase 2 Study Group 1Vall d’Hebron University Hospital, Barcelona, Spain; 2St. Michael’s Hospital, University of Toronto, Toronto, ON, Canada; 3EMD Serono Research & Development Institute, Inc (a business of Merck KGaA, Darmstadt, Germany), Billerica, MA; 4Institute of Neuropathology and Department of Neurology, University Medical Center, Gottingen, Germany
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ID: DXT37
Effect of Teriflunomide on Brain Volume Loss in Patients with Relapsing Multiple Sclerosis of Differing Ages in TEMSO
Jiwon Oh,1 Jens Wuerfel,2 Bhupendra O. Khatri,3 Aaron E. Miller,4 Jihad Said Inshasi,5 Albert Saiz,6 Alex L. Lublin,7 Elizabeth M. Poole,7 Till Sprenger8,9 1University of Toronto, Toronto, ON, Canada; 2Medical Imaging Analysis Center (MIAC AG) and Department of Biomedical Engineering, University of Basel, Basel, Switzerland; 3Center for Neurological Disorders at Wheaton Franciscan Healthcare, Milwaukee, WI; 4Icahn School of Medicine at Mount Sinai, The Corinne Goldsmith Dickinson Center for Multiple Sclerosis, New York, NY; 5Dubai Medical College, Dubai, United Arab Emirates; 6Department of Neurology, Hospital Clinic and Institut d’Investigacions Biomèdiques August Pi i Sunyer, University of Barcelona, Barcelona, Spain; 7Sanofi, Cambridge, MA; 8DKD Helios Klinik Wiesbaden, Wiesbaden, Germany; 9University Hospital Basel, Basel, Switzerland
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ID: DXT38
Effects of Ozanimod on Information Processing Speed: Findings from the Phase 3 SUNBEAM and DAYBREAK Extension Trials
John DeLuca,1 Jeffrey A. Cohen,2 Bruce A.C. Cree,3 Hongjuan Liu,4 James K. Sheffield,4 Diego Silva,4 Giancarlo Comi,5 Ludwig Kappos6
1Kessler Foundation, West Orange, New Jersey and Departments of Physical Medicine and Rehabilitation, and Neurology, Rutgers – New Jersey Medical School, Newark, NJ; 2Mellen Center, Cleveland Clinic, Cleveland, OH; 3Department of Neurology and Department of Ophthalmology, UCSF Weill Institute for Neurosciences, University of California San Francisco, San Francisco, CA; 4Bristol-Myers Squibb, Summit, NJ; 5Department of Neurology, San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, Italy; 6Neurologic Clinic and Policlinic, Departments of Medicine, Clinical Research, Biomedicine and Biomedical Engineering, University Hospital of Basel, Basel, Switzerland
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DISEASE MODIFYING THERAPIES PART 2

ID: DXT40
Effect of the S1P1/5 Receptor Modulator Ozanimod on Cognitive Processing Speed in Subjects with Relapsing Multiple Sclerosis: Design of the ENLIGHTEN Study
Jon V. Riolo,1 Ling Yang,1 Thomas Rano,1 Robert Zivadinov,2 Lauren B. Krupp,3 Jonathan Calkwood,4 Olaf Stuve,5 Robert T. Naismith,6 Diego Silva,1 John DeLuca7
1Bristol-Myers Squibb, Summit, NJ; 2Buffalo Neuroimaging Analysis Center, Department of Neurology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, The State University of New York, Buffalo, NY; 3Stony Brook Technology Park, East Setauket, NY; 4Minneapolis Clinic of Neurology, Golden Valley, MN; 5UT Southwestern Medical Center, Dallas, TX; 6Washington University School of Medicine, St. Louis, MO; 7Kessler Foundation, West Orange, New Jersey and Departments of Physical Medicine and Rehabilitation, and Neurology, Rutgers – New Jersey Medical School, Newark, NJ
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ID: DXT41
Eculizumab Benefits a Broad Range of Patients with Aquaporin-4 Antibody–Positive Neuromyelitis Optica Spectrum Disorder: The Phase 3 PREVENT Study
Kazuo Fujihara,1,2,3 Achim Berthele,4 Ho Jin Kim,5 Michael Levy,6,7 Ichiro Nakashima,2,8 Celia Oreja-Guevara,9 Jacqueline Palace,10 Sean J. Pittock,11 Murat Terzi,12 Natalia Totolyan,13 Shanthi Viswanathan,14 Kai-Chen Wang,15,16 Amy Pace,17 Marcus Yountz,17 Larisa Miller,17 Imran Tanvir,17 Roisin Armstrong,17 Dean Wingerchuk18
1Southern TOHOKU Research Institute for Neuroscience (STRINS), Koriyama, Japan; 2Tohoku University, Sendai, Japan; 3Fukushima Medical University, Fukushima City, Japan; 4Technical University of Munich, Munich, Germany; 5National Cancer Center, Goyang, Korea, Republic of (South); 6Massachusetts General Hospital and Harvard Medical School, Boston, MA; 7Johns Hopkins University, Baltimore, MD; 8Tohoku Medical and Pharmaceutical University, Sendai, Japan; 9Hospital Universitario Clinico San Carlos, Madrid, Spain; 10John Radcliffe Hospital, Oxford, United Kingdom; 11Mayo Clinic, Rochester, MN; 12Ondokuz Mayis University, Samsun, Turkey; 13First Pavlov State Medical University of St Petersburg, St Petersburg, Russian Federation; 14Kuala Lumpur Hospital, Kuala Lumpur, Malaysia; 15National Yang Ming University, Taipei, Taiwan; 16Cheng-Hsin General Hospital, Taipei, Taiwan; 17Alexion Pharmaceuticals, Boston, MA; 18Mayo Clinic, Scottsdale, AZ
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ID: DXT42
Rationale and Design of CLASSIC-MS Study Evaluating Long-Term Efficacy for Patients with Multiple Sclerosis Treated with Cladribine Tablets

Alexey Boyko,1 Jorge Correale,2 Gilles Edan,3 Mark S. Freedman,4 Gavin Giovannoni,5 Xavier Montalban,6,7 Kottil Rammohan,8 Thomas P. Leist,9 Dusan Stefoski,10 Bassem Yamout,11 Belen Garcia-Alonso,12 Aida Aydemir,13 Elisabetta Verdun di Cantogno,12 CLASSIC-MS Study Group
1Pirogov Russian National Research Medical University, Moscow, Russia; 2FLENI Institute, Buenos Aires, Argentina; 3Department of Neurology, University Hospital of Rennes, France; 4University of Ottawa and the Ottawa Hospital Research Institute, Ottawa, ON, Canada; 5Queen Mary University of London, London, United Kingdom; 6Centre d’Esclerosi Múltiple de Catalunya (Cemcat), Hospital Universitario Vall d’Hebron, Barcelona, Spain; 7St. Michael’s Hospital, University of Toronto, Toronto, ON, Canada; 8Department of Neurology, Multiple Sclerosis Center, University of Miami, Miami, FL; 9Jefferson University Hospital, Philadelphia, PA; 10Rush Medical College, Chicago, IL; 11Department of Neurology, American University of Beirut Medical Center, Beirut, Lebanon; 12Merck KGaA, Darmstadt, Germany; 13EMD Serono Research & Development Institute Inc, Billerica, MA

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ID: DXT43
Analyses of the Effect of Baseline Age on the Efficacy and Safety of Siponimod in Patients with Active Secondary Progressive Multiple Sclerosis from the EXPAND Study
Le H. Hua,1 Amit Bar-Or,2 Fred D. Lublin,3 Xiangyi Meng,4 Wendy Su,4 Bruce A.C. Cree,5 Robert J. Fox6
1Lou Ruvo Center for Brain Health, Las Vegas, NV; 2Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA; 3Icahn School of Medicine at Mount Sinai, New York, NY; 4Novartis Pharmaceuticals Corporation, East Hanover, NJ; 5Department of Neurology, UCSF Weill Institute for Neurosciences, University of California San Francisco, San Francisco, CA; 6Cleveland Clinic, Cleveland, OH
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ID: DXT44
Real-World Patterns of Outcomes in Patients with Multiple Sclerosis Who Are Adherent versus Non-Adherent to Disease Modifying Treatments over 6 Years
Lilyana Amezcua,1 Mitzi J. Williams,2 Jia Zhou,3 Terrie Livingston31University of Southern California, Los Angeles, CA; 2Joi Life Wellness Group, Newnan, GA; 3EMD Serono Inc, Rockland, MA
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ID: DXT45
Pharmacist-Based Intervention for Improving Baseline Laboratory Monitoring for Patients on Multiple Sclerosis Disease-Modifying Therapies
Lisa Aquillano,1 Kristina Murphy,2 Neil Lava,1 Diana Vargas1
1Neurology and 2Pharmacy, The Emory Clinic, Atlanta, GA
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ID: DXT46
Cognitive Performance and Disability Across Age Groups in Teriflunomide-Treated Patients in the TeriPRO Study
Lori H. Travis,1 Dennis Chinchilla,2 Bhupendra O. Khatri,3 José Meca-Lallana,4 Min Su Park,5 Patrick Vermersch,6 Alex Lublin,7 Elizabeth M. Poole,7 Patricia K. Coyle8
1Phoenix Neurological Associates, Phoenix, AZ; 2Department of Neurology, CIMA Hospital, San José, Costa Rica; 3Center for Neurological Disorders at Wheaton Franciscan Healthcare, Milwaukee, WI; 4Hospital Virgen de la Arrixaca, Universidad Católica San Antonio de Murcia, Murcia, Spain; 5Department of Neurology, Yeungnam University Hospital, Daegu, Korea, Republic of (South); 6University of Lille, INSERM U995, CHU Lille, Lille, France; 7Sanofi, Cambridge, MA; 8Stony Brook University, Stony Brook, NY
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ID: DXT48
Efficacy of Subcutaneous Interferon Beta-1a in Patients with a First Clinical Demyelinating Event: REFLEX Study – Outcomes in Patients Stratified by 2017 McDonald Criteria
Mark S. Freedman,1 Ludwig Kappos,2 Giancarlo Comi,3 Nicola De Stefano,4 Sanjeev Roy,5 Delphine Issard6
1University of Ottawa and the Ottawa Hospital Research Institute, Ottawa, ON, Canada; 2Neurologic Clinic and Policlinic, Departments of Medicine, Clinical Research, Biomedicine and Biomedical Engineering, University Hospital of Basel, Basel, Switzerland; 3Department of Neurology and Institute of Experimental Neurology, University Vita-Salute San Raffaele, Ospedale San Raffaele, Milan, Italy; 4Department of Neurological and Behavioural Sciences, University of Siena, Siena, Italy; 5Merck KGaA, Aubonne, Switzerland; 6Cytel Inc, Geneva, Switzerland
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ID: DXT49
Post Hoc Analysis of Efficacy of Cladribine Tablets in Patients with Relapsing-Remitting Multiple Sclerosis Aged Over and Under 30 Years in the CLARITY Study
Mark S. Freedman,1 Gabriel Pardo,2 Nicola De Stefano,3 Julie Aldridge,4 Sana Syed,4 Yann Hyvert,5 Andrew Galazka,6 Caroline Lemieux,7 Gavin Giovannoni8
1University of Ottawa and the Ottawa Hospital Research Institute, Ottawa, ON, Canada; 2Oklahoma Medical Research Foundation, Oklahoma City, OK; 3University of Siena, Siena, Italy; 4EMD Serono Inc, Billerica, MA; 5Merck KGaA, Darmstadt, Germany; 6Merck, Aubonne, Switzerland; 7EMD Serono Inc, Mississauga, ON, Canada; 8Blizard Institute of Cell and Molecular Science, London, United Kingdom
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ID: DXT50
Prevalence of Serious Adverse Pregnancy Outcomes After Exposure to Interferon Beta Before or During Pregnancy: Stratification by Characteristics of Pregnant Women with Multiple Sclerosis in a RegisterBased Cohort Study in Finland and Sweden
Marta Korjagina,1 Katja Hakkarainen,1 Sarah Burkill,2 Yvonne Geissbuehler,3 Meritxell Sabidó,4 Achint Kumar,5 Kiliana Suzart-Woischnik,6 Riho Klement,1 Jan Hillert,2 Auli Verkkoniemi-Ahola,7,8 Shahram Bahmanyar,2 Scott Montgomery,2,9,10 Pasi Korhonen,1 European Interferon Beta Pregnancy Study Group and Nordic MS Pregnancy & Interferon Beta Study Group
1StatFinn and EPID Research (an IQVIA company), Espoo, Finland; 2Karolinska Institute, Stockholm, Sweden; 3Novartis Pharma AG, Basel, Switzerland; 4Merck KGaA, Darmstadt, Germany; 5Biogen, Cambridge, MA; 6Bayer AG, Berlin, Germany; 7University of Helsinki, Helsinki, Finland; 8Helsinki University Hospital, Helsinki, Finland; 9Orebro University, Orebro, Sweden; 10University College London, London, United Kingdom
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ID: DXT51
High Rates of Adherence to Oral Diroximel Fumarate Are Observed and Sustained in Relapsing Multiple Sclerosis Patients
Mary Kay Fink,1 Elzbieta Jasinska,2 Pavle Repovic,3 Cortnee Roman,4 Hailu Chen,5 Shivani Kapadia,5 Sibyl Wray6
1Department of Neurology, Washington University School of Medicine, St. Louis, MO; 2Collegium Medicum UJK and Clinical Center, RESMEDICA, Kielce, Poland; 3Multiple Sclerosis Center, Swedish Neuroscience Institute, Seattle, WA; 4Rocky Mountain Multiple Sclerosis Clinic, Salt Lake City, UT; 5Biogen, Cambridge, MA; 6Hope Neurology, Knoxville, TN
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ID: DXT52
Efficacy and Safety of Eculizumab in Patients with Neuromyelitis Optica Spectrum Disorder Previously Treated with Rituximab: The Phase 3 PREVENT Study
Michael Levy,1,2 Achim Berthele,3 Ho Jin Kim,4 Kazuo Fujihara,5,6,7 Ichiro Nakashima,6,8 Celia Oreja-Guevara,9 Jacqueline Palace,10 Sean J. Pittock,11 Murat Terzi,12 Natalia Totolyan,13 Shanthi Viswanathan,14 Kai-Chen Wang,15,16 Amy Pace,17 Marcus Yountz,17 Diane Lawson,17 Eva Laudon-Meyer,18 Dean Wingerchuk19
1Massachusetts General Hospital and Harvard Medical School, Boston, MA; 2Johns Hopkins University, Baltimore, MD; 3Technical University of Munich, Munich, Germany; 4National Cancer Center, Goyang, Korea, Republic of (South); 5Southern TOHOKU Research Institute for Neuroscience (STRINS), Koriyama, Japan; 6Tohoku University, Sendai, Japan; 7Fukushima Medical University, Fukushima City, Japan; 8Tohoku Medical and Pharmaceutical University, Sendai, Japan; 9Hospital Universitario Clinico San Carlos, Madrid, Spain; 10John Radcliffe Hospital, Oxford, United Kingdom; 11Mayo Clinic, Rochester, MN; 12Ondokuz Mayis University, Samsun, Turkey; 13First Pavlov State Medical University of St Petersburg, St Petersburg, Russian Federation; 14Kuala Lumpur Hospital, Kuala Lumpur, Malaysia; 15National Yang Ming University, Taipei, Taiwan; 16Cheng-Hsin General Hospital, Taipei, Taiwan; 17Alexion Pharmaceuticals, Boston, MA; 18Alexion Pharmaceuticals, Zurich, Switzerland; 19Mayo Clinic, Scottsdale, AZ
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ID: DXT53
Multiple Sclerosis Clinical Phenotypes: Using Technology to Educate Patients and Optimize Treatment
Elaine Rudell,1 Patty Peterson,1 Andrea Griffin,2 Michele F. Ingram,1 Michelle Fabian3
1@Point of Care, Livingston, NJ; 2Multiple Sclerosis Association of America, Cherry Hill, NJ; 3Icahn School of Medicine, Corinne Goldsmith Dickinson Center for Multiple Sclerosis, New York, NY
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ID: DXT54
Assessment of the Discontinuation Rates of Disease-Modifying Therapy in Veterans with Multiple Sclerosis
Naomi Wu,1 Eric Williamson,2 Jeremy Liu,1 Christine Lava,1 Hyojin Suh,1 Andrea Hanssen,2 Sunita Dergalust1
1Pharmacy and 2Neurology, VA Greater Los Angeles Healthcare System, Los Angeles, CA
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ID: DXT55
Herpes Zoster Virus (HZV) Infections Among Multiple Sclerosis Patients Treated with Various Disease-Modifying Therapies
Nicola Carlisle,1 Sam I. Hooshmand,1 Michelle Maynard,2 Leah Hoffman,3 Ahmed Z. Obeidat4
1Neurology, Medical College of Wisconsin and Affiliated Hospitals, Milwaukee, WI; 2Neurosciences, Froedtert and the Medical College of Wisconsin, Milwaukee, WI; 3Pharmacy, Froedtert and the Medical College of Wisconsin, Milwaukee, WI; 4Neurology, Medical College of Wisconsin, Milwaukee, WI
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ID: DXT56
Potential Weight Changes Among Patients with Multiple Sclerosis Undergoing Treatment with Ocrevus (Ocrelizumab)
Olivia Wei,1 Elizabeth S. Gromisch,2,3,4 Lindsay O. Neto,2,5 Jennifer A. Ruiz,2,4 Peter Wade2,3
1Frank H. Netter MD School of Medicine at Quinnipiac University, North Haven, CT; 2Mandell Center for Multiple Sclerosis, Mount Sinai Rehabilitation Hospital, Trinity Health Of New England, Hartford, CT; 3Department of Neurology, University of Connecticut School of Medicine, Farmington, CT; 4Departments of Rehabilitative Medicine and Medical Sciences, Frank H. Netter MD School of Medicine at Quinnipiac University, North Haven, CT; 5Department of Rehabilitative Medicine, Frank H. Netter MD School of Medicine at Quinnipiac University, North Haven, CT
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ID: DXT57
FAST: Faster and Safe Administration of Tysabri
Patricia A. Pagnotta
Neurology Associates, PA, and MS Center of Greater Orlando, Maitland, FL
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ID: DXT58
Reduction of Risk of Secondary Progressive Multiple Sclerosis within 2 Years of Treatment with Cladribine Tablets: An Analysis of the CLARITY Study
Patrick Vermersch,1 Gavin Giovannoni,2,3 Per Soelberg-Sorensen,4 Kottil Rammohan,5 Stuart Cook,6 Birgit Keller,7 Sanjeev Roy8
1University of Lille, Lille, France; 2Blizard Institute of Cell and Molecular Science, London, United Kingdom; 3Queen Mary University of London, London, United Kingdom; 4Department of Neurology, Danish MS Center, University of Copenhagen, Copenhagen, Denmark; 5Department of Neurology, Multiple Sclerosis Center, University of Miami, Miami, FL; 6Rutgers, The State University of New Jersey, New Jersey Medical School, Newark, NJ; 7Merck KGaA, Darmstadt, Germany; 8Merck KGaA, Aubonne, Switzerland
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ID: DXT59
The CLARITY Study: Efficacy Outcomes Among Patients Who Received Disease-Modifying Drugs Prior to Treatment with Cladribine Tablets
Patrick Vermersch,1 Kottil Rammohan,2 Doris Damian,3 Dominic Jack,4 Gerard Harty,3 Schiffon L. Wong3
1University of Lille, Lille, France; 2Department of Neurology, Multiple Sclerosis Center, University of Miami, Miami, FL; 3EMD Serono Inc, Billerica, MA; 4Merck KGaA, Darmstadt, Germany
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ID: DXT60
Correlations Between Four Common Measures of Cognition in Patients with Secondary Progressive Multiple Sclerosis
Ralph H.B. Benedict,1 Xiangyi Meng,2 Amit Bar-Or,3 Bruce A.C. Cree,4 Robert J. Fox,5 Patrick Vermersch,6 Wendy Su,2 Ludwig Kappos7
1University at Buffalo, State University of New York, Buffalo, NY; 2Novartis Pharmaceuticals Corporation, East Hanover, NJ; 3Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA; 4Department of Neurology, UCSF Weill Institute for Neurosciences, University of California San Francisco, San Francisco, CA; 5Mellen Center for Multiple Sclerosis, Cleveland Clinic, Cleveland, OH; 6Department of Neurology, University of Lille, CHU Lille, Lille, France; 7Departments of Medicine, Clinical Research, Biomedicine, and Biomedical Engineering, Neurologic Clinic and Policlinic, University Hospital Basel, University of Basel, Basel, Switzerland
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ID: DXT61
Injection-Related Reactions with Subcutaneous Administration of Ofatumumab in Relapsing Multiple Sclerosis: Pooled Analysis of the Phase 3 ASCLEPIOS I and II Trials
Ratnakar Pingili,1 Amit Bar-Or,2 Jeffrey A. Cohen,3 Patricia K. Coyle,4 Anne H. Cross,5 Stephen L. Hauser,6 Ludwig Kappos,7 Cecile Kerloeguen,8 Ayan Das Gupta,9 Valentine Jehl,8 Dieter A. Haering,8 Krishnan Ramanathan,8 Martin Merschhemke8
1Novartis Pharmaceuticals Corporation, East Hanover, NJ; 2Center for Neuroinflammation and Experimental Therapeutics and Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA; 3Department of Neurology, Mellen MS Center, Neurological Institute, Cleveland Clinic, Cleveland, OH; 4Stony Brook University, Stony Brook, NY; 5Department of Neurology, Division of Neuroimmunology, Washington University School of Medicine, St Louis, MO; 6University of California, San Francisco, San Francisco, CA; 7Neurologic Clinic and Policlinic, Departments of Medicine, Clinical Research, Biomedicine and Biomedical Engineering, University Hospital of Basel, Basel, Switzerland; 8Novartis Pharma AG, Basel, Switzerland; 9Novartis Healthcare Pvt Ltd, Hyderabad, India
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ID: DXT62
Real-World Treatment Patterns in Patients with Multiple Sclerosis Using Disease-Modifying Therapies
Robert J. Fox,1 Rina Mehta,2 Tim Pham,2 Julie Park,3 Kathleen Wilson,3 Machaon Bonafede3
1Cleveland Clinic, Cleveland, OH; 2Bristol-Myers Squibb, Summit, NJ; 3IBM Watson Health, Cambridge, MA
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ID: DXT63
Associations Between Treatment Satisfaction, Medication Beliefs, and Adherence to Disease-Modifying Therapies in Patients with Multiple Sclerosis Among Adult Saudis: A Tertiary Care Center Experience
Rola F. Alarieh
King Fahad Medical City, Riyadh, Saudi Arabia
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ID: DXT64
Evaluation of Rituximab Regimens and Outcomes in Neuromyelitis Optica Patients from a Single Academic Medical Center: A Retrospective Chart Review
Ryan Fuller,1 Stephanie Witek,2 Lauren Long1
1Neurology and 2Pharmacy, Hospital of the University of Pennsylvania, Philadelphia, PA
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ID: DXT65
Longitudinal Disability Follow-up in Patients with 6-Month Confirmed Disability Improvement or Worsening in the CARE-MS and Extension Studies
Samuel F. Hunter,1 Darren P. Baker,2 Mark Ozog,2 Elizabeth M. Poole,2 Luke Chung,2 Patrick Vermersch,3 Rany A. Aburashed,4 Raed Alroughani,5 Dominique Dive,6 Ho Jin Kim,7 Jan Lycke,8 Richard A.L. Macdonell,9 Carlo Pozzilli,10 Heinz Wiendl,11 on behalf of the CARE-MS I, CARE-MS II, CAMMS03409, and TOPAZ investigators
1Advanced Neurosciences Institute, Franklin, TN; 2Sanofi, Cambridge, MA; 3University of Lille, INSERM U995, CHU Lille, Lille, France; 4Institute for Neurosciences and Multiple Sclerosis, Owosso, MI; 5Amiri Hospital, Sharq, Kuwait; 6University Hospital Centre of Liège, Liège, Belgium; 7Research Institute and Hospital, National Cancer Center, Goyang, Korea, Republic of (South); 8Institute of Neuroscience and Physiology, University of Gothenburg, Gothenburg, Sweden; 9Austin Health and Florey Institute of Neuroscience and Mental Health, Melbourne, VIC, Australia; 10Sapienza University, Rome, Italy; 11Department of Neurology, University of Münster, Münster, Germany
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ID: DXT66
Clinical Benefits of Eculizumab Monotherapy in Neuromyelitis Optica Spectrum Disorder: Findings from the Phase 3 PREVENT Study
Sean J. Pittock,1 Achim Berthele,2 Ho Jin Kim,3 Kazuo Fujihara,4,5,6 Michael Levy,7,8 Ichiro Nakashima,5,9 Celia Oreja-Guevara,10 Jacqueline Palace,11 Murat Terzi,12 Natalia Totolyan,13 Shanthi Viswanathan,14 Kai-Chen Wang,15,16 Amy Pace,17 Marcus Yountz,17 Larisa Miller,17 Guido Sabatella,17 Roisin Armstrong,17 Dean Wingerchuk18
1Mayo Clinic, Rochester, MN; 2Technical University of Munich, Munich, Germany; 3National Cancer Center, Goyang, Korea, Republic of (South); 4Southern TOHOKU Research Institute for Neuroscience (STRINS), Koriyama, Japan; 5Tohoku University, Sendai, Japan; 6Fukushima Medical University, Fukushima City, Japan; 7Massachusetts General Hospital and Harvard Medical School, Boston, MA; 8Johns Hopkins University, Baltimore, MD; 9Tohoku Medical and Pharmaceutical University, Sendai, Japan; 10Hospital Universitario Clinico San Carlos, Madrid, Spain; 11John Radcliffe Hospital, Oxford, United Kingdom; 12Ondokuz Mayis University, Samsun, Turkey; 13First Pavlov State Medical University of St. Petersburg, St. Petersburg, Russian Federation; 14Kuala Lumpur Hospital, Kuala Lumpur, Malaysia; 15National Yang Ming University, Taipei, Taiwan; 16Cheng-Hsin General Hospital, Taipei, Taiwan; 17Alexion Pharmaceuticals, Boston, MA; 18Mayo Clinic, Scottsdale, AZ
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ID: DXT67
Cognitive Functions over the Course of 5 Years in Multiple Sclerosis Patients Treated with DiseaseModifying Therapies
Serkan Ozakbas,1 Cavid Baba,2 Taha Aslan,2 Ozge Sagici,2 Yasemin Simsek,2 Pinar Yigit2
1Department of Neurology, Dokuz Eylul University, Izmir, Turkey; 2Dokuz Eylul University, Izmir, Turkey
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ID: DXT69
One-Year Interim Analysis of Real-World Patient-Reported Outcomes in Relapsing-Remitting Multiple Sclerosis Patients Transitioning to Alemtuzumab (PRO-ACT Study)
Sibyl Wray,1 Francois Jacques,2 Jacqueline Nicholas,3 Susan Mozzicato,4 Benjamin Guikema,4 Elizabeth M. Poole,4 Tamara A. Miller5
1Hope Neurology, Knoxville, TN; 2Clinique Neuro-Outaouais, Gatineau, QC, Canada; 3OhioHealth Multiple Sclerosis Center, Columbus, OH; 4Sanofi, Cambridge, MA; 5Advanced Neurology of Colorado, Fort Collins, CO
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ID: DXT70
Clinical Characteristics and Outcomes of Peginterferon Beta-1a Treatment by Age: A Subgroup Analysis of the Plegridy Observational Program
Sibyl Wray,1 Marco Salvetti,2 Gereon Nelles,3 Arman Altincatal,4 Megan C. Vignos,4 Achint Kumar,4 Maria L. Naylor4
1Hope Neurology, Knoxville, TN; 2Sapienza University, S. Andrea Hospital, Rome, Italy; 3Neurology, NeuroMed Campus Hohenlind, Cologne, Germany; 4Biogen, Cambridge, MA
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ID: DXT71
Efficacy and Safety of Teriflunomide in Patients with Relapsing-Remitting Multiple Sclerosis of Varying Disease Duration: Analysis of Pooled Clinical Trials
Stanley Cohan,1 Albert Saiz,2 David Rog,3 Mauro Zaffaroni,4 Sandra Vukusic,5 Steve Vucic,6 Jiwon Oh,7 Klaus Tiel-Wilck,8 Anat Achiron,9 Darren P. Baker,10 Janneke Wingerden,11 Elizabeth M. Poole,10 Bhupendra O. Khatri12
1Providence Brain and Spine Institute, Portland, OR; 2Department of Neurology, Hospital Clinic and Institut d’Investigacions Biomèdiques August Pi i Sunyer, University of Barcelona, Barcelona, Spain; 3Manchester Centre for Clinical Neurosciences, Salford, United Kingdom; 4MS Centre, Gallarate Hospital, Gallarate, Italy; 5University Hospital of Lyon, Bron, France; 6Department of Medicine, University of Sydney, Sydney, NSW, Australia; 7University of Toronto, Toronto, ON, Canada; 8Neurologisches Facharztezentrum Berlin, Berlin, Germany; 9Sheba Medical Center, Ramat Gan, Israel; 10Sanofi, Cambridge, MA; 11Sanofi, Amsterdam, Netherlands; 12Center for Neurological Disorders at Wheaton Franciscan Healthcare, Milwaukee, WI
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ID: DXT73
Updated Safety of Cladribine Tablets in the Treatment of Patients with Multiple Sclerosis: Integrated Safety Analysis and Postapproval Data
Stuart Cook,1 Gavin Giovannoni,2,3 Thomas P. Leist,4 Giancarlo Comi,5 Sana Syed,6 Axel Nolting,7 Doris Damian,6 Regina Schick7
1Rutgers, The State University of New Jersey, New Jersey Medical School, Newark, NJ; 2Blizard Institute of Cell and Molecular Science, London, United Kingdom; 3Queen Mary University of London, London, United Kingdom; 4Jefferson University Hospital, Philadelphia, PA; 5Department of Neurology and Institute of Experimental Neurology, Universita Vita-Salute San Raffaele, Milan, Italy; 6EMD Serono Inc, Billerica, MA; 7Merck KGaA, Darmstadt, Germany
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ID: DXT74
An Analysis of the Relationship Between Cladribine Dose and Risk of Malignancies in Patients with Multiple Sclerosis
Stuart Cook,1 Gavin Giovannoni,2,3 Thomas P. Leist,4 Giancarlo Comi,5 Axel Nolting,6 Elke Sylvester,6 Dominic Jack,6 Doris Damian,7 Andrew Galazka8
1Rutgers, The State University of New Jersey, New Jersey Medical School, Newark, NJ; 2Blizard Institute of Cell and Molecular Science, London, United Kingdom; 3Queen Mary University of London, London, United Kingdom; 4Jefferson University Hospital, Philadelphia, PA; 5Department of Neurology and Institute of Experimental Neurology, Universita Vita-Salute San Raffaele, Milan, Italy; 6Merck KGaA, Darmstadt, Germany; 7EMD Serono Inc, Billerica, MA; 8Merck, Aubonne, Switzerland
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ID: DXT75
Switches to Established and Recently Approved Oral Disease-Modifying Therapies: Comparison of Patient Clinical Profiles and Therapy Selection Drivers
Virginia R. Schobel,1 Jennifer Robinson2
1Neurology Market Intelligence, Spherix Global Insights, Exton, PA; 2President, Spherix Global Insights, Exton, PA
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ID: DXT76
First-Line Ocrelizumab Use for Relapsing-Remitting Multiple Sclerosis in the United States: Trend and Comparison to Glatiramer Acetate and Dimethyl Fumarate-
Virginia R. Schobel,1 Jennifer Robinson2
1Neurology Market Intelligence, Spherix Global Insights, Exton, PA; 2President, Spherix Global Insights, Exton, PA
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ID: DXT77
Alemtuzumab Maintains Efficacy on Clinical and Magnetic Resonance Imaging Lesion Outcomes, Including Slowing of Brain Volume Loss, Over 9 Years in Relapsing-Remitting Multiple Sclerosis Patients: CARE-MS II Follow-up (TOPAZ Study)
Barry A. Singer,1 Raed Alroughani,2 Ann D. Bass,3 Simon Broadley,4 Yang Mao-Draayer,5 Hans-Peter Hartung,6 Eva Kubala Havrdova,7 Ho Jin Kim,8 Kunio Nakamura,9 Carlos Navas,10 Alex Rovira,11 Krzysztof W. Selmaj,12 Patrick Vermersch,13 Sibyl Wray,14 Zia Choudhry,15 Nadia Daizadeh,15 Salman Afsar,15 Giancarlo Comi,16 on behalf of the CAREMS II, CAMMS03409, and TOPAZ Investigators
1The MS Center for Innovations in Care, Missouri Baptist Medical Center, St. Louis, MO; 2Amiri Hospital, Sharq, Kuwait; 3Neurology Center of San Antonio, San Antonio, TX; 4Griffith University School of Medicine, Gold Coast Campus, Southport, QLD, Australia; 5University of Michigan Medical School, Ann Arbor, MI; 6Department of Neurology, UKD, Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany; 7First Medical Faculty, Charles University, Prague, Czech Republic; 8Research Institute and Hospital of National Cancer Center, Goyang, Korea, Republic of (South); 9Cleveland Clinic, Cleveland, OH; 10Clínica Universitaria Colombia, Bogotá, Colombia; 11Vall d’Hebron University Hospital, Barcelona, Spain; 12University of Warmia and Mazury, Olsztyn, Poland; 13University of Lille, INSERM U995, CHU Lille, Lille, France; 14Hope Neurology, Knoxville, TN; 15Sanofi, Cambridge, MA; 16University Vita-Salute San Raffaele, Milan, Italy
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ID: DXT78
The FLUENT Study: Changes in Immune Cell Profile, and in Clinical and Safety Outcomes, in Fingolimod-Treated Patients with Relapsing Multiple Sclerosis
Yang Mao-Draayer,1 Jeffrey A. Cohen,2 Amit Bar-Or,3 May H. Han,4 Barry A. Singer,5 Nina Jaitly,6 Scott Kolodny,6 Chelsea Elam,6 Xiangyi Meng,6 Marina Ziehn,6 Bruce A.C. Cree7>br> 1Autoimmunity Center of Excellence, Multiple Sclerosis Center, University of Michigan, Ann Arbor, MI; 2Mellen Center, Cleveland Clinic, Cleveland, OH; 3Center for Neuroinflammation and Experimental Therapeutics and Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA; 4Stanford University, Stanford, CA; 5Missouri Baptist Medical Center, St. Louis, MO; 6Novartis Pharmaceuticals Corporation, East Hanover, NJ; 7Department of Neurology, UCSF Weill Institute for Neurosciences, University of California San Francisco, San Francisco, CA
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ID: DXT79
Efficacy of Ocrelizumab Treatment on Cognitive Functions in Persons with Multiple Sclerosis
Serkan Ozakbas,1 Ozge Sagici,2 Zuhal Abasiyanik,2 Tuba Ozdogar,2 Pinar Yigit2
1Department of Neurology, Dokuz Eylul University, Izmir, Turkey; 2Dokuz Eylul University, Izmir, Turkey
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EPIDEMIOLOGY AND GENETICS

ID: EPI01
Determining the Effect of Early Versus Later Diagnosis of Multiple Sclerosis on Long-Term Prognosis in a Real-World Setting
Jikku Zachariah,1 Rebecca Schorr,2 Tim Quezada,1 Thomas F. Scott1,3
1Department of Neurology and Neuroscience Institute, Allegheny General Hospital, Allegheny Health Network, Pittsburgh, PA; 2Highmark Health Data Science R&D, Highmark Health, Pittsburgh, PA; 3Department of Neurology, Drexel University College of Medicine, Philadelphia, PA
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ID: EPI02
Motor Impairment in Multiple Sclerosis: Analysis from the North American Registry for Care and Research in Multiple Sclerosis (NARCRMS)
Kottil Rammohan,1 David Li,2 June Halper,3 Sara McCurdy Murphy,4 Trent Wallace,5 Lisa Patton,4 Sarah Chrisant,5 Chao Zheng,6 Seema Khurana6
1Department of Neurology, Multiple Sclerosis Center, University of Miami, Miami, FL; 2The University of British Columbia, Vancouver, BC, Canada; 3CEO-CMSC, Hackensack, NJ; 4CRB, Social & Scientific Systems, Inc, Silver Spring, MD; 5CRB, Social & Scientific Systems, Inc, Durham, NC; 6University of Miami, Miami, FL
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ID: EPI03
Increase in Family Recurrence in Patients Diagnosed with Multiple Sclerosis in the Years 2017- 2019 in Hispanic Population of Puerto Rico
Viviana Martinez, Astrid Diaz, Cristina M. Rubi, Ivonne Vicente, Angel Chinea
San Juan Multiple Sclerosis Center, Guaynabo, PR
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ID: EPI04
Diet Quality and Nutritional Adequacy of Micronutrients Among People with Relapsing-Remitting Multiple Sclerosis: An Analysis of Weighed Food Records
Tyler J. Titcomb,1 Linda G. Snetselaar,2 Terry L. Wahls1
1Department of Internal Medicine and 2Department of Epidemiology, University of Iowa, Iowa City, IA
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FAMILY AND CAREGIVERS

ID: FAM01
Characterizing Predictors of Resilience Among Family Caregivers of People with Advanced Multiple Sclerosis Disability: Work in Progress
Afolasade Fakolade,1 Odessa McKenna,1 Mark S. Freedman,2 Marcia Finlayson,3 Amy E. Latimer-Cheung,4 Lara A. Pilutti1
1Interdisciplinary School of Health Sciences, University of Ottawa, Ottawa, ON, Canada; 2University of Ottawa and the Ottawa Hospital Research Institute, Ottawa, ON, Canada; 3School of Rehabilitation Therapy, Queen’s University, Kingston, ON, Canada; 4Kinesiology and Health Studies, Queen’s University, Kingston, ON, Canada
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ID: FAM02
Understanding Units of Energy: Key to Communicating Multiple Sclerosis Fatigue
Angela Jones,1 Anne L. Diaz2
1Health Services, Clark County School District, Las Vegas, NV; 2Kent, WA
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INTERNET AND INFORMATION SERVICES

ID: IIS01
North American Registry for Care and Research in Multiple Sclerosis (NARCRMS) Model for Implementing OpenClinica Insight for Data Sharing and Visualization
Peter Gilbertson,1 Trent Wallace,2 Lydia Rogers,1 Sara McCurdy Murphy,3 Lisa Patton,3 Sarah Chrisant,2 David Li,4 June Halper,5 Kottil Rammohan6 
1Social & Scientific Systems, Inc, Silver Spring, MD; 2CRB, Social & Scientific Systems, Inc, Durham, NC; 3CRB, Social & Scientific Systems, Inc, Silver Spring, MD; 4University of British Columbia, Vancouver, BC, Canada; 5CEO-CMSC, Hackensack, NJ; 6Department of Neurology, Multiple Sclerosis Center, University of Miami, Miami, FL
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IMAGING

ID: IMG01
Conformance to CMSC Magnetic Resonance Imaging (MRI) Guidelines in a Real-World Multicenter MRI Dataset

Sophie Vercruyssen,1 Arne Brys,1 Melissa Verheijen,1 Brandon Steach,2 Eline Van Vlierberghe,2 Diana M. Sima,1 Dirk Smeets1
1R&D, icometrix, Leuven, Belgium; 2icometrix, Chicago, IL

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ID: IMG02
Optic Nerve Head Volume Is Significantly Decreased in Pediatric Multiple Sclerosis and Not Pediatric Myelin Oligodendrocyte Glycoprotein (MOG)– Related Disorders
Giulia Longoni,1 Tara Berenbaum,2 Sunil K. Yadav,3,4 Ella M. Kadas,3,4 Michael J. Wan,5 Arun Reginald,5 Donald Mabbott,6 Alexander Brandt,3 E. Ann Yeh1
1Department of Paediatrics, Division of Neurology, The Hospital for Sick Children, Toronto, ON, Canada; 2Department of Neurosciences and Mental Health, The Hospital for Sick Children, Toronto, ON, Canada; 3Charité – Universitätmedizin, Berlin, Germany; 4Nocturne GmbH, Berlin, Germany; 5Ophthalmology and Vision Sciences, The Hospital for Sick Children, Toronto, ON, Canada; 6Research Institute, Neuroscience and Mental Health Program, The Hospital for Sick Children, Toronto, ON, Canada
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ID: IMG03
Cerebellar Connectivity Is Associated with Verbal Memory Impairment in Multiple Sclerosis
Mark D. Zuppichini,1 Kathryn West,2 Dinesh Sivakolundu,3 Darin T. Okuda,4 Bart Rypma3
1School of Behavioral and Brain Sciences, University of Texas at Dallas, Richardson, TX; 2Center for BrainHealth, Dallas, TX; 3School of Behavioral and Brain Sciences, University of Texas at Dallas, Richardson, TX; 4UT Southwestern Medical Center, Dallas, TX
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ID: IMG04
The Association Between Magnetic Resonance Imaging Brain Volumes and Computerized Cognitive Scores of People with Multiple Sclerosis
Daniel Golan,1 Jared Srinivasan,2 Olivia Kaczmarek,2 Jonathan Bautista,2 Myassar Zarif,2 Barbara Bumstead,2 Marijean Buhse,2 Lori Fafard,2 Jeffrey Wilken,3 Cynthia Sullivan,4 Timothy Fratto,3 Eline Van Vlierberghe,5 Diana Sima,6 Wim Van Hecke,6 Mark Gudesblatt2
1Rapparport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel; 2South Shore Neurologic Associates, Patchogue, NY; 3Washington Neuropsychology Research Group, Washington, DC; 4Nursing, State University of New York at Stony Brook, Stony Brook, NY; 5icometrix, Chicago, IL; 6Icometrix, Leuven, Belgium
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ID: IMG05
Analysis of Demyelinizing Injuries in Magnetic Resonance Imaging in People with Multiple Sclerosis
Dyana Fernandes Sr., Ana Canzonieri, Juliana Rhein, Liliana Russo
Associação Brasileira de Esclerose Múltipla, São Paulo/SP, Brazil
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MULTIDISCIPLINARY CARE

ID: MDC01
Social Assistance Intervention in Multiple Sclerosis
Alice Estevo Dias,1 Priscila S. Santos2
1Scientific Research and 2Social Service, Brazilian Association of Multiple Sclerosis, Sao Paulo, Brazil
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ID: MDC02
Is a 2-Week Intensive Day Program an Effective Approach to Provide Outpatient Services for People with Multiple Sclerosis?
Clare T. Hartigan,1 Tracy Walker2
1Multiple Sclerosis Outpatient Rehabilitation and 2Virginia C. Crawford Research Institute, Shepherd Center, Atlanta, GA
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ID: MDC03
The Waiting Room: A Successful Experience in the Multiple Sclerosis Care and Treatment Center (CATEM)
Ivone R. Fernandes, Ana C. Sena, Maria L. Santos, Rodrigo N. Fonseca, Vanessa D. Vale, Natali M. Marques, Elisa Melo, Charles P. Tilbery
Santa Casa of Misericordia, São Paulo, Brazil
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ID: MDC04
MS Brain Health Global Quality Standards: MS Nurses' Role in Development and Implementation

Amy Bowen,1 Kathleen Costello,2 Jodi Haartsen,3 Lucy Eberhard,4 George Pepper,5 Jeremy Hobart6 and Gavin Giovannoni7
1NHS England/Improvement – London Region, London, UK; 2National Multiple Sclerosis Society, New York, NY, USA;
3Eastern Health MS Service, Eastern Health, Melbourne, VIC, Australia; 4PharmaGenesis London, London, UK; 5Shift.ms, Leeds, UK; 6Plymouth University Peninsula Schools of Medicine and Dentistry, Plymouth, UK; 7Queen Mary University London, Blizard Institute, Barts and the London School of Medicine and Dentistry, London, UK

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ID: MDC05
Implementation of a Pharmacist-Led Immunization Program in a Center for Comprehensive Multiple Sclerosis (MS) Care
Lauren Long, Ryan Fuller
Neurology, Hospital of the University of Pennsylvania, Philadelphia, PA
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ID: MDC06
The African American Experience and Multiple Sclerosis
Marie LeGrand
Multiple Sclerosis Association of America, Chicago, IL
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ID: MDC07
The Impact of the Nurse Practitioner Model of Care within Multiple Sclerosis
Meaghan Osborne, Suyinn Chong
Neurology, Royal Brisbane and Women’s Hospital, Brisbane, Australia
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ID: MDC08
Late-Onset Multiple Sclerosis: Comorbidity and Disease Progression
Smathorn Thakolwiboon,1 Mirla Avila,1 Pavida Pachariyanon,2 Jie Pan,1 Amputch Karukote,1 Gyeongmo Sohn1
1Neurology and 2Internal Medicine, Texas Tech University Health Sciences Center, Lubbock, TX
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ID: MDC09
Comparing Patient Perceptions on Multiple Sclerosis Management and Care: A Subanalysis of Geographic Differences
Sarah A. Morrow,1,2 Alexey Boyko,3 Heidi Thompson,4 Maija Pontaga,5 Nektaria Alexandri6
1Western University, London, ON, Canada; 2Clinical Neurological Sciences, London Health Sciences Centre, London, ON, Canada; 3Pirogov Russian National Research Medical University, Moscow, Russia; 4Neurology, Southern Health & Social Care Trust, Portadown, United Kingdom; 5MS in the 21st Century, Riga, Latvia; 6Neurology and Immunology, Merck KGaA, Darmstadt, Germany
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METHODS OF CARE

ID: MOC01
Understanding the Health Care Provider– Patient Relationship in Treating Multiple Sclerosis
Beth Schneider
MyHealthTeams, San Francisco, CA
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ID: MOC02
Cancelling Clinic Appointments: What Factors Are Associated with Higher Rates of Cancellations in Patients with Multiple Sclerosis?
Elizabeth S. Gromisch,1,2,3,4 Aaron P. Turner,5,6,7 Steven L. Leipertz,7 John Beauvais,2,8 Jodie K. Haselkorn5,6,7,9
1Mandell Center for Multiple Sclerosis, Mount Sinai Rehabilitation Hospital, Trinity Health Of New England, Hartford, CT; 2Psychology Service, VA Connecticut Healthcare System, West Haven, CT; 3Department of Neurology, University of Connecticut School of Medicine, Farmington, CT; 4Departments of Rehabilitative Medicine and Medical Sciences, Frank H. Netter MD School of Medicine at Quinnipiac University, North Haven, CT; 5Department of Rehabilitation Medicine, University of Washington, Seattle, WA; 6Rehabilitation Care Service, VA Puget Sound Health Care System, Seattle, WA; 7Multiple Sclerosis Center of Excellence West, Veterans Affairs, Seattle, WA; 8Department of Psychiatry, Yale University School of Medicine, New Haven, CT; 9Department of Epidemiology, University of Washington, Seattle, WA
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ID: MOC03
From Therapy Enrollment to First Dose: A Quality Improvement Initiative for Multiple Sclerosis
Care Jamie Bolling,1 Ryan McNiff,2 Tirisham V. Gyang,1 Carlos Vervloet Sollero,1 Aaron Carlson1
1Neurology, University of Florida, Gainesville, FL; 2UF Health, University of Florida, Gainesville, FL
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ID: MOC04
Nurse Telephone Encounters in a Multiple Sclerosis Clinic in 2020
Janice Lake, Colleen Harris, Sharon Peters, Jackie Gaythorpe
University of Calgary MS Clinic, Calgary, AB, Canada
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ID: MOC05
Pioneering Multiple Sclerosis Center Program with MSHA Certification to Improve Patient Care and Experience
Jennifer R. Hillner, Jennifer L. Rusk
Neurology/MS, OSF HealthCare Illinois Neurological Institute, Peoria, IL
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ID: MOC06
Conceptualizing Access Through the Perspectives of Canadians with Multiple Sclerosis
Julie Petrin,1 Mary Ann McColl,1 Catherine Donnelly,1 Marcia Finlayson2
1Rehabilitation Sciences, Queen’s University, Kingston, ON, Canada; 2School of Rehabilitation Therapy, Queen’s University, Kingston, ON, Canada
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ID: MOC07
Access to Health Care for Canadians with Multiple Sclerosis: Prioritizing Concerns
Julie Petrin,1 Mary Ann McColl,2 Simon French,3 Catherine Donnelly,2 Marcia Finlayson1
1School of Rehabilitation Therapy, Queen’s University, Kingston, ON, Canada; 2Rehabilitation Sciences, Queen’s University, Kingston, ON, Canada; 3Chiropractic, MacQuarie University, Sydney, Australia
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ID: MOC08
Use of a Clinical Decision Support Tool to Support Monitoring and Care of Patients with Multiple Sclerosis Receiving Disease-Modifying Therapy

Lisa M. Mitchell,1 Mitchell T. Wallin,2 Natasha M. Antonovich3
1VA Maryland Health Care System, Multiple Sclerosis Center of Excellence – East, Baltimore, MD; 2Washington, DC VAMC, MS Center of Excellence, Washington, DC; 3Orlando VA Medical Center, Multiple Sclerosis Center of Excellence – East, Orlando, FL

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ID: MOC09
Multiple Sclerosis Disease Impact Monitoring: Longitudinal Exploration of the Relationship of Ocular Coherence Tomography to Computerized Cognitive Testing
Mark Gudesblatt,1 Jared Srinivasan,1 Olivia Kaczmarek,1 Glen Doniger,2 Daniel Golan,3 Jeffrey Wilken,4 Timothy Fratto,4 Robert C. Sergott5
1South Shore Neurologic Associates, Patchogue, NY; 2NeuroTrax Corporation, Modiin, Israel; 3Rapparport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel; 4Washington Neuropsychology Research Group, Washington, DC; 5Wills Eye Hospital, Philadelphia, PA
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ID: MOC11
Improving Understanding of Clinical Phenotype for Patients with Multiple Sclerosis: Design and Implementation of Smarttools in Electronic Health Record Systems
Thomas Grader-Beck,1 Yujie Wang,2 Kathryn C. Fitzgerald,2 Peter A. Calabresi,2 Ellen M. Mowry2
1School of Medicine, Johns Hopkins University, Baltimore, MD; 2Neurology, Johns Hopkins University School of Medicine, Baltimore, MD
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ID: MOC12
Changing Language to Acknowledging Patients’ Perceptions of Treatment in Multiple Sclerosis Care
Tim O’Maley
Nursing, MS Queensland, Brisbane, QLD, Australia
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NEUROIMMUNOLOGY AND DISEASE MODELS

ID: NDM01
Efficacy of the Influenza Vaccine in Multiple Sclerosis Patients: A Systematic Review and Metaanalysis
Jackie T. Nguyen,1 Patrick Hardigan,1 Michelle Demory Beckler,1 Marc Kesselman2
1Dr. Kiran C. Patel College of Allopathic Medicine, Nova Southeastern University, Davie, FL; 2Dr. Kiran C. Patel College of Osteopathic Medicine, Nova Southeastern University, Davie, FL
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NONIMAGING BIOMARKERS

ID: NIB01
Higher Sensitivity of Quantitative Reverse Transcriptase–Polymerase Chain Reaction Compared with Flow Cytometry for Quantification of B Cells After AntiCD20 Monoclonal Antibody Therapy
Ismahane Touil Allaoui,1 Marija Colic,1 David Leppert,2 Friedrich Raulf,1 Gisbert Weckbecker1
1Novartis Pharma AG, Basel, Switzerland; 2Neurologic Clinic and Policlinic, University Hospital Basel, University of Basel, Basel, Switzerland
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ID: NIB02
Quantification of Smooth Pursuit Dysfunction in Multiple Sclerosis
Neda Dastgheyb,1 Miryam Palomino,2 Annalise Miner,2 Revere P. Kinkel,2 Dorion Liston,3 Jennifer S. Graves4
1University of California San Diego (UCSD), La Jolla, CA; 2UCSD, San Diego, CA; 3NeuroFit, Mountain View, CA; 4Neurosciences, UCSD, San Diego, CA
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