1. John F. Kurtzke Memorial Lecture:
   Computerized Screening for Cognitive Dysfunction in the MS Clinic
   Stephen M. Rao, PhD
2. Challenges in MS Care: Opportunities for Advocacy
   Jeffrey English, MD, Chair
   • Welcome and Introductions
     Jeffrey B. English, MD
   • Challenges for the MS Center
     R. Terry Smith, CEO
   • Social Services, DME, and Rehabilitation Access
     Bari Talente
   • Physician Challenges
     Jeffrey B. English, MD
   • MACRA/MIPS, Quality Measures and Registries
     Sarah Benish, MD
   • Specialty Home Centers
     Carlo Tornatore, MD
3. Building Advocacy Efforts
   Derek Smith, MD, Chair
   • Welcome and Introduction
     Derek Smith, MD
   • Experience of AAN Brain PAC
     Lily Jung Henson, MD
   • Approaches to Access to Care Issues
     Derek Smith, MD
   • Future Directions and Conclusion
     Derek Smith, MD

1. Pediatric MS
   Brenda Banwell, MD, Chair
   • Treatment of Pediatric MS Update 2018
     Brenda Banwell, MD
   • Advanced MRI Imaging Insights in the Earliest Aspect of MS
     Giulia Fadda, MD
   • Clinical Features of MS in Children: New Insight in the MOG-era
     Yael Hacohen, MD
     This speaker has opted not to publish this presentation.
2. An MS Health Professional’s Guide to Cannabis
   Allen Bowling, MD, PhD
3. Fundamentals of MS Care: Part I
   A Case-Based Approach to Disease Management 2018
   Constance B. Easterling, RN, MSN, ARNP, MSCN, Moderator
   • History of Multiple Sclerosis
     Thomas J. Murray, MD, FRCP(C), MACP
   • Epidemiology, Immunology, Pathophysiology, Characteristics and Natural History
     Bruce Cohen, MD
   • Making the Diagnosis: Disease Mimics, Use of Paraclinical Tools, Phenotypes
     Derrick Robertson, MD
   • Primary Progressive MS: Diagnosis, Clinical Course, and Long-term Management
     Patricia K. Coyle, MD
   • RRMS: Current Treatment Options, Considerations in Choosing Treatment, Acute Relapse Management
     John Rinker, MD
   • Psychological Impact of MS
     Anthony Feinstein, MD, PhD
   • Providing Comprehensive Care with the Multidisciplinary Team
     Mitzi Joi Williams, MD
   • Integrative Medicine in MS
     Megan Weigel, DNP, ARNP-C, MSCN
4. Integrative Medicine and MS
   Allen Bowling, MD, PhD, Chair
   • Introduction: MS as a Lifestyle Disease, “Pearls” for Clinical Practice, and Research Update
     Allen Bowling, MD, PhD
   • Comorbidity and MS—Opportunity Knocks? Insights from Linked Health Administrative and Clinical Data
     Helen Tremlett, PhD
   • Dietary Modification and Multiple Sclerosis Course
     Kathryn Fitzgerald, ScD, ScM
   • Mindfulness in Motion: A Multimodal Intervention Beneficial for Both Patient and Healthcare Provider
     Maryanna D. Klatt, PhD
     This speaker has opted not to publish this presentation.
5. Practical Considerations in Relapse Management and Disease Modifying Therapy (DMT) Decision Making (all presenters)
   Stephanie Agrella, RN, MSN,APRN, ANP-BC, MSCN, Chair
   • Identification and Definition of an Acute MS Relapse vs. Pseudo-relapse
     Amy Dix, MPAS, PA-C, MSCS
   • Relapse Treatment, Determining Need and Other Considerations
     Bryan Walker, MSH, PA-C, MSCS
   • DMT Options and Decision Making Regarding Switches
     Stephanie Agrella, RN, MSN, APRN, ANP-BC, MSCN
6. Addressing Provider Burnout Through the Use of Relationship Centered Care and Communication: An Interactive and Experientially Driven Program (all presenters)
   Matthew Sacco, PhD, Chair
   • What Do We Know About Professional Burnout & How to Combat It?
     Matthew Sacco, PhD
   • How Can Relationship-centered Communication Be Part of the Solution?
     Samantha Domingo, PsyD
   • How Can Relationship-centered Teaming be Part of the Solution?
     Amy Windover, PhD
   • Panel Q&A/Discussion: How to Incorporate RCC/Exercises/Interventions into their Respective Environments
     Matthew Sacco, PhD; Samantha Domingo, PsyD; Amy Windover, PhD; Lael Stone, MD
7. Fundamentals of MS Care: Part II
   Multidisciplinary Approach to Symptom Management
   Beverly Layton, RN, BSN, CCRC, MSCN, Moderator
   • Managing Pain and Sensory Symptoms
     Marie Moore, MSN, ARNP, MSCN
   • Managing Sleep Disorders
     David Brandes, MS, MD, FAAN, MSC
   • Managing Symptoms of Elimination
     Marie Namey, RN, MS, MSCN
   • Effects of MS on Menopause, Pregnancy, and Sexual Function
     Patricia K. Coyle, MD
8. Comprehensive Care in Advanced MS
   Rachael Stacom, MS, ANP-BC, MSCN, Chair
   • Living with Advanced MS: An Approach to Patient-centered Care
     Rachael Stacom, MS, ANP-BC, MSCN
   • Symptom Management Strategies to Relieve Suffering in Advanced MS
     Stephen Krieger, MD
   • Using Adaptive Equipment and Assistive Technology to Maximize Function in Advanced MS
     Elaine Castelluccio, PT, MPT, MSCS
   • Empowering the Individual with a Cognitive Impairment and their Care Partners to Maximize Choice, Independence and Quality of Life
     Nettie Harper, CTRS
9. PLATFORM PRESENTATIONS: Disease Assessment and Management
   • Clinical Cannabis Interprofessional Education: Program Development and Provider Knowledge
     Kim Jones, PhD
   • Optimal Inter-Eye Difference Thresholds in Retinal Nerve Fiber Layer and Ganglion Cell Layer Thickness for Predicting a Unilateral Optic Nerve Lesion in Multiple Sclerosis
     Rachel Nolan, BA
   • Rationale and Design of the Traditional Versus Early Aggressive Therapy for MS (TREAT-MS) Trial
     Scott Newsome, DO
   • Derivation and Validation of a Predictive Model for 30-Day Readmission Risk in Patients with Multiple Sclerosis
     Kanika Sharma, MD
   • Myelin Signal Isolated MRI (siMRI): A Novel Technique to Quantify Myelin Integrity Reveals Loss of Brain Architectonics in Multiple Sclerosis
     Tatiana Wolfe, PhD
     This speaker has opted not to publish this presentation.
   • The North American Registry for Care and Research in Multiple Sclerosis
     Kottil Rammohan, MD
   • Obesity at Onset Impacts the Early Clinical Presentation of Multiple Sclerosis
     Farren Briggs, PhD, ScM
   • Pediatric-Onset Multiple Sclerosis Is Associated with Reduced Parental Health-Related Quality of Life and Family Functioning
     Julia O’Mahony, BSc
10. Primary Care Needs through the Spectrum of MS
    Marijean Buhse, PhD, RN, NP-C, MSCN, Chair
    • Erikson’s Theory of Psychological Development
      Marijean Buhse, PhD, RN, NP-C, MSCN
    • Children and Young Adults with MS: Striking a Balance between Medical and Psychosocial Needs
      Lauren Krupp, MD
    • Primary Care Needs and Social Implications of MS in the Early and Middle Aged Adult
      Patricia Melville, NP, MSCN
    • Keeping Well Despite MS: The Older Person with MS
      Marijean Buhse, PhD, MP-C, MSCN
11. Use of Digital Tools for Patient Self-Management and Monitoring: 10 Years in, What Have We Learned?-Part 1
    Riley Bove, MD, Chair
    • From Information Seekers to Informants: The Rise of Online and Smartphone Tools to Collect and Disseminate MS Research – Which Tools to Use?
      Riley Bove, MD
      This speaker has opted not to publish this presentation.
    • Stepping It Up: Measuring and Increasing Activity Across the MS Ability Spectrum
      Valerie Block, PT, DPTSc
      This speaker has opted not to publish this presentation.
    • Taking the Full Measure of the Mind: From Measuring to Improving Mental Health
      Adam Kaplin, MD, PhD
    • Using Telehealth Tools to Increase Access and Reduce Barriers To Care
      Riley Bove, MD
      This speaker has opted not to publish this presentation.
12. Donald Paty Memorial Lecture: DMT Debates – Stopping, Switching, Re-starting
    Patricia K. Coyle, MD

1. Pediatric MS
   Brenda Banwell, MD, Chair
   • Treatment of Pediatric MS Update 2018
     Brenda Banwell, MD
   • Advanced MRI Imaging Insights in the Earliest Aspect of MS
     Giulia Fadda, MD
   • Clinical Features of MS in Children: New Insight in the MOG-era
     Yael Hacohen, MD
     This speaker has opted not to publish this presentation.
2. Real World Risks of Complex Therapies
   Joseph Berger, MD; Eric Williamson, MD
   • Infections, Malignancies and Other Risks with Newer Disease Modifying Therapy
   • PML and Disease Modifying Therapies
   • Infections other than PML with Disease Modifying Therapies
   • Risk of Malignancy
3. Fundamentals of MS Care: Part I
   A Case-Based Approach to Disease Management 2018
   Constance B. Easterling, RN, MSN, ARNP, MSCN, Moderator
   • History of Multiple Sclerosis
     Thomas J. Murray, MD, FRCP(C), MACP
   • Epidemiology, Immunology, Pathophysiology, Characteristics and Natural History
     Bruce Cohen, MD
   • Making the Diagnosis: Disease Mimics, Use of Paraclinical Tools, Phenotypes
     Derrick Robertson, MD
   • Primary Progressive MS: Diagnosis, Clinical Course, and Long-term Management
     Patricia K. Coyle, MD
4. DMTs – What Does the Future Hold in MS Treatment?
   Fred D. Lublin, MD, Chair
   • Hx of Rx (MRI, BSeron, Safety, Orals, High Efficacy)
     Fred D. Lublin, MD
   • Future of Current DMTs – Expanded Use, Peds, New Uses
     Andrew D. Goodman, MD
   • MS DMT Pipeline New Approaches
     Ilana Katz Sand, MD
   • Protection, Repair and Regeneration
     Robert P. Lisak, MD, FRCP(E), FAAN, FANA
5. Practical Considerations in Relapse Management and Disease Modifying Therapy (DMT) Decision Making (all presenters)
   Stephanie Agrella, RN, MSN, APRN, ANP-BC, MSCN, Chair
   • Identification and Definition of an Acute MS Relapse vs. Pseudo-relapse
     Amy Dix, MPAS, PA-C, MSCS
   • Relapse Treatment, Determining Need and Other Considerations
     Bryan Walker, MSH, PA-C, MSCS
   • DMT Options and Decision Making Regarding Switches
     Stephanie Agrella, RN, MSN, APRN, ANP-BC, MSCN
6. Fundamentals of MS Care: Part I (afternoon session)
   A Case-Based Approach to Disease Management 2018
   Constance B. Easterling, RN, MSN, ARNP, MSCN, Moderator
   • RRMS: Current Treatment Options, Considerations in Choosing Treatment, Acute Relapse Management
     John Rinker, MD
   • Psychological Impact of MS
     Anthony Feinstein, MD, PhD
   • Providing Comprehensive Care with the Multidisciplinary Team
     Mitzi Joi Williams, MD
   • Integrative Medicine in MS
     Megan Weigel, DNP, ARNP-C, MSCN
7. Hot Topics in MRI and MS: Gadolinium and Brain Atrophy in Clinical Practice
   David K.B. Li, MD, FRCPC, Co-Chair; Anthony Traboulsee, MD, FRCPC, Co-Chair
   • Introduction-Gadolinium Safety and Gadolinium Use in MS
     David K.B. Li, MD, FRCPC
   • Gadolinium Safety Issues
     Heejun Kang, MD
   • Gadolinium in MS Practice
     David K.B. Li, MD, FRCPC
   • Introduction-Brain Atrophy and Brain Atrophy Assessment in MS
     Anthony Traboulsee, MD, FRCPC
   • Brain Atrophy and MS
     Jiwon Oh, MD, PhD, FRCPC
   • Brain Atrophy Assessment in MS Practice
     Anthony Traboulsee, MD, FRCPC
8. Immunology (Basic and Advanced)
   Scott Newsome, DO, MSCS, FAAN, Chair
   • How Does the Immune System Protect Us?
     Lisa Fox, PA-C
   • What Causes CNS Inflammation in MS?
     Scott Newsome, DO, MSCS, FAAN
   • Immune Insights into Multiple Sclerosis from EAE: Musings of a MD (mouse doctor)
     Gregory F. Wu, MD, PhD
   • Immune Consequences of Current MS Therapies
     Amy Lovett-Racke, PhD
9. Obesity, Vascular Disease Risk Factors and MS: Impact, Current Management and Future Directions
   This session was developed with support from the VA MS Centers of Excellence
   Jodie K. Haselkorn, MD, MPH, Chair
   • Obesity and Vascular Disease Risk Factors in MS – Impact and Patient Management: Current State and Clinical Perspective
     Vijayshree Yadav, MD, MCR, FANA
     This speaker has opted not to publish this presentation.
   • Caloric Restriction and Inflammation in MS: Diet, Gut Microbiome, and Inflammation Emerging Relationship
     Michael Lane, MD
     This speaker has opted not to publish this presentation.
   • Obesity and Vascular Disease Risk Factors – Lessons and New Directions from Endocrinologist’s Perspective in Optimal Patient Management
     Jonathan Q. Purnell, MD
10. Progressive MS and the International Progressive MS Alliance
    Robert Fox, MD, Chair
    • Introduction
      Robert Fox, MD
    • Progressive MS Alliance: An Overview
      Alan Thompson, MD, FRCP, FAcadMedSci
    • Executive Leadership
      Cynthia Zagieboylo
    • Challenge Awards
      Robert Fox, MD
    • Collaborative Network Awards
      Sridar Narayanan, MD, PhD
    • Collaborative Network Awards
      Linda Ottoboni, MD
    • Collaborative Network Awards
      Francisco Quintana, PhD
    • Future Strategies
      Timothy Coetzee, PhD
11. PLATFORM PRESENTATIONS: Disease Modifying Therapy
    • Confirmed Disability Improvement in Patients with Relapsing Multiple Sclerosis in the Open-Label Extension Period of the Pooled Opera Trials
      Robert Naismith, MD
    • Durable Improvements in MRI Disease Activity and Brain Volume Loss with Alemtuzumab in RRMS Patients: 7-Year Follow-up of Care-MS II
      Daniel Pelletier, MD
    • Active RRMS Patients Show Disability Improvements in Each Functional System Following Treatment with Alemtuzumab: Results from Care-MS II Extension
      Samuel Hunter, MD
    • Impact of Ocrelizumab on Cognition in Patients at Increased Risk of Developing Progressive Disease
      Ralph Benedict, PhD
    • Effects of Fingolimod on Magnetic Resonance Imaging Outcomes in Patients with Pediatric-Onset Multiple Sclerosis: Results from the Phase 3 Paradigms Study
      Tanuja Chitnis, MD
    • Efficacy and Safety of Ozanimod Versus Interferon Beta 1A
      Bruce Cree, MD, PhD
    • Phase 2 Multicenter Study Results of Ublituximab, a Novel Glycoengineered Anti-CD20 Monoclonal Antibody (mAb), in Patients with Relapsing Forms of Multiple Sclerosis (RMS)
      Edward Fox, MD, PhD
12. PLATFORM PRESENTATIONS: Disease Assessment and Management
    • Clinical Cannabis Interprofessional Education: Program Development and Provider Knowledge
      Kim Jones, PhD
    • Optimal Inter-Eye Difference Thresholds in Retinal Nerve Fiber Layer and Ganglion Cell Layer Thickness for Predicting a Unilateral Optic Nerve Lesion in Multiple Sclerosis
      Rachel Nolan, BA
    • Rationale and Design of the Traditional Versus Early Aggressive Therapy for MS (TREAT-MS) Trial
      Scott Newsome, DO
    • Derivation and Validation of a Predictive Model for 30-Day Readmission Risk in Patients with Multiple Sclerosis
      Kanika Sharma, MD
    • Myelin Signal Isolated MRI (siMRI): A Novel Technique to Quantify Myelin Integrity Reveals Loss of Brain Architectonics in Multiple Sclerosis
      Tatiana Wolfe, PhD
      This speaker has opted not to publish this presentation.
    • The North American Registry for Care and Research in Multiple Sclerosis
      Kottil Rammohan, MD
    • Obesity at Onset Impacts the Early Clinical Presentation of Multiple Sclerosis
      Farren Briggs, PhD, ScM
    • Pediatric-Onset Multiple Sclerosis Is Associated with Reduced Parental Health-Related Quality of Life and Family Functioning
      Julia O’Mahony, BSc
13. Pharmacology – Part 1
    Jacquelyn Bainbridge, PharmD, MSCS, Moderator
    • The Proof is in the Pudding: Evaluating Current Pharmacokinetic Data to Make Informed Disease Modifying Therapy (DMT) Treatment Selection and Changes
      Enrique Alvarez, MD, PhD
    • From Annualized Relapse Rates and Beyond
      Ellen Whipple, PharmD
14. Donald Paty Memorial Lecture: DMT Debates – Stopping, Switching, Re-starting
    Patricia K. Coyle, MD

1. John Whitaker Research Track Platform Presentations
   Michael K. Racke, MD, Chair
   • Metabolomics Analysis Identifies Abnormal Bile Acid Metabolism in Multiple Sclerosis
     Leah Mische, BS
   • Variations within a 255,348 Base-Pair Region of Chromosome 1 That Show Association with Serum Prolactin Levels or MS Status
     Samantha Jack, MS
   • Acute Effects of High-Intensity Interval Exercise on Mood and Enjoyment Outcomes in Multiple Sclerosis
     Elizabeth Hubbard, PhD
   • Engaging the MS Community on Exercise Services for Those Living in Rural Australia
     Yvonne Learmonth, PhD
2. Clinical Neuroanatomy of the Brain and Spinal Cord
   Aliza Ben-Zacharia, DrNP, ANP-BC, MSCN; Stephen Krieger, MD
3. Presidential Lecture: Neurorehabilitation in MS: Past, Present, Future
   Alan Thompson, MD, FRCP, FA-cadMedSci
4. Regulation of CNS Inflammation 
   Francisco Quintana, PhD, Co-Chair; Ari Waisman, PhD, Co-Chair
   • Regulation of CNS Inflammation
     Francisco Quintana, PhD
   • Control of Immunopathology in CNS Autoimmunity
     Thomas Korn, MD
     This speaker has opted not to publish this presentation.
   • Role of Hyper-Activated Neutrophils in Autoimmune Neuroinflammation
     Etty (Tika) Benveniste, PhD
   • Mechanisms That Regulate the Pathogenic Functions of T Cells
     Estelle Bettelli, PhD
     This speaker has opted not to publish this presentation.
   • Cytokine Regulation of CNS Inflammation
     Ari Waisman, PhD
   • Dysregulated Immune Communication Can Cause Neuroinflammation
     Burkhard Becher, PhD
   • Targeting Phosphodiesterase-8 (PDE8) Controls Autoimmune CNS Inflammation by Mechanisms Distinct from PDE4 Inhibition
     Stefan Brocke, MD
   • Myeloperoxidase as a Therapeutic Target in Multiple Sclerosis
     Bonnie Dittel, PhD
5. Immunology (Basic and Advanced)
   Scott Newsome, DO, MSCS, FAAN, Chair
   • How Does the Immune System Protect Us?
     Lisa Fox, PA-C
   • What Causes CNS Inflammation in MS?
     Scott Newsome, DO, MSCS, FAAN
   • Questions
   • Immune Insights into Multiple Sclerosis from EAE: Musings of a MD (mouse doctor)
     Gregory F. Wu, MD, PhD
   • Immune Consequences of Current MS Therapies
     Amy Lovett-Racke, PhD
6. John Whitaker Memorial Lecture:
   New Insights into MS Pathology using Synchrotron X-ray Fluorescence Imaging (SXRF)
   Claudia F. Lucchinetti, MD
   This speaker has opted not to publish this presentation.
7. John Whitaker Research Track Faculty Presentations
   Michael K. Racke, MD, Chair
   • Lifestyle Interventions for Cognitive and Affective Dysfunction in Multiple Sclerosis
     Ruchika Prakash, PhD
     This speaker has opted not to publish this presentation.
   • Chronic Pain and Cognition: Implications and Interventions
     Dawn Ehde, PhD
   • Cognitive Rehabilitation in Multiple Sclerosis
     John DeLuca, PhD
   • The Intersection of Neurocognitive and Affective Functioning in MS
     Peter Arnett, PhD
8. Obesity, Vascular Disease Risk Factors and MS: Impact, Current Management and Future Directions
   This session was developed with support from the VA MS Centers of Excellence
   Jodie K. Haselkorn, MD, MPH, Chair
   • Obesity and Vascular Disease Risk Factors in MS – Impact and Patient Management: Current State and Clinical Perspective
     Vijayshree Yadav, MD, MCR, FANA
     This speaker has opted not to publish this presentation.
   • Caloric Restriction and Inflammation in MS: Diet, Gut Microbiome, and Inflammation Emerging Relationship
     Michael Lane, MD
     This speaker has opted not to publish this presentation.
   • Obesity and Vascular Disease Risk Factors – Lessons and New Directions from Endocrinologist’s Perspective in Optimal Patient Management
     Jonathan Q. Purnell, MD
9. World Epidemiology- What Can We Learn From What is Changing/Not Changing and From Landmark Investigations Across Different Parts of the World
   Alberto Ascherio, MD, DrPH, Chair
   • Australia/New Zealand
     Robyn M. Lucas, BSc MBChB MPH&TM PhD MHE FAFPHM
   • Europe
     Maura Pugliatti, MD, PhD
   • U.S. and Canada
     Kassandra Munger, ScD
10. Progressive MS and the International Progressive MS Alliance
    Robert Fox, MD, Chair
    • Introduction
      Robert Fox, MD
    • Progressive MS Alliance: An Overview
      Alan Thompson, MD, FRCP, FAcadMedSci
    • Executive Leadership
      Cynthia Zagieboylo
    • Challenge Awards
      Robert Fox, MD
    • Collaborative Network Awards
      Sridar Narayanan, MD, PhD
    • Collaborative Network Awards
      Linda Ottoboni, MD
    • Collaborative Network Awards
      Francisco Quintana, PhD
    • Future Strategies
      Timothy Coetzee, PhD
11. Stem Cells for MS: An Update
    Mark Freedman, MD, Chair
    • Introduction
      Mark Freedman, MD
    • Haematopoietic Stem Cells for Resetting the Immune System Following Immunoablation
      Harry Atkins, MD, FRCP(C)
    • The Biological Basis for Using Mesenchymal Stem Cells to Treat MS
      Antonio Uccelli, MD
    • MSCs – Variables which Affect Outcomes
      Jacques Galipeau, MD, FRCP(C)
    • Science Hype and Marketing of Unproven Stem Cell Therapies
      Timothy Caulfield, LLM, FRSC, FCAHS
      This speaker has opted not to publish this presentation.
12. Blocking Lipid Metabolism in MS – A New Class of Medications
    John Nieland, PhD, Chair
    • New Ways of Looking at MS: A Systemic Disease
      John Nieland, PhD
    • Beyond Fats: Predicting Disease Onset and Relapse using Machine Learning Identification of Metabolic Markers
      Angelique Corthals, PhD
    • The Role of Dysregulated Lipid Metabolism in an EAE Model of Mice Mimicking the Inuit CPT1a Mutation
      Anne Skottrup Morkholt, PhD
    • Is There a Difference for the Role of Lipid Metabolism in Multiple Sclerosis, Parkinson’s Disease and Amyotrophic Lateral Sclerosis?
      Michael Sloth Trabjerg, MD, PhD student

1. MS Infusion Therapies:
   Inside and Outside of the Infusion Room
   Colleen Harris, MN, NP, MSCN, Chair

• Overview and Introduction
  Colleen Harris, MN, NP, MSCN
• Therapy Selection and Pre–infusion Processes
  Denise Bruen, MSN
• Inside the Infusion Room
  Nancy Bogle, RN, BSN

1. Screening for Cognitive Problems in MS: Traditional and Computerized Measures for Screening
   Jeffrey Wilken, PhD; Frederick Foley, PhD
   • Computerized Measures for Screening
     Jeffrey Wilken, PhD
   • Traditional Measures for Screening
     Frederick Foley, PhD
2. Informal Caregiving: From Theory to Practice (all presenters)
   Deborah Miller, PhD, LISW, Chair
   • The Family Caregiving Experience
     Deborah Miller, PhD, LISW
   • The Stress and Burnout that Results from Family Caregiving
     Matthew Sacco, PhD
   • Interventions to Support Family Members as Caregivers Who Experience Stress and Burnout
     Lucille Carriere, PhD
   • Care Giver Panel Discussion
   • Wrap Up/Conclusions
     Deborah Miller, PhD, LISW; Panel
3. Cognitive Dysfunction and Rehabilitation Techniques
   John DeLuca, PhD, Chair
   • Cognition and Cognitive Rehabilitation in MS: An Overview
     John DeLuca, PhD
   • Principles of Cognitive Rehabilitation: Application Through Clinical Trials in MS
     Yael Goverover, PhD
   • Theory-based Techniques in Memory Rehabilitation: Overview of Two Encoding-based Treatments
     Erica Weber, PhD
4. John Whitaker Research Track Faculty Presentations
   Michael K. Racke, MD, Chair
   • Lifestyle Interventions for Cognitive and Affective Dysfunction in Multiple Sclerosis
     Ruchika Prakash, PhD
     This speaker has opted not to publish this presentation.
   • Chronic Pain and Cognition: Implications and Interventions
     Dawn Ehde, PhD
   • Cognitive Rehabilitation in Multiple Sclerosis
     John DeLuca, PhD
   • The Intersection of Neurocognitive and Affective Functioning in MS
     Peter Arnett, PhD
5. Depression in MS
   Anthony Feinstein, MD, PhD, Chair
   • Screening and Assessment of Depression in MS
     Peter Arnett, PhD
   • The Effects of Depression on Cognitive Function in People with MS
     Anthony Feinstein, MD, PhD
   • Exercise and Depression in MS: Evidence of Benefits, Modifiers, and Prescription
     Robert W. Motl, PhD
   • Pharmacologic Management of Depression in MS
     Aaron Mackie, MD
6. Comprehensive Care in Advanced MS
   Rachael Stacom, MS, ANP-BC, MSCN, Chair
   • Living with Advanced MS: An Approach to Patient-centered Care
     Rachael Stacom, MS, ANP-BC, MSCN
   • Symptom Management Strategies to Relieve Suffering in Advanced MS
     Stephen Krieger, MD
   • Using Adaptive Equipment and Assistive Technology to Maximize Function in Advanced MS
     Elaine Castelluccio, PT, MPT, MSCS
   • Empowering the Individual with a Cognitive Impairment and their Care Partners to Maximize Choice, Independence and Quality of Life
     Nettie Harper, CTRS
7. PLATFORM PRESENTATIONS: Cognition/Psychosocial
   • Impact of a Cognitive Rehabilitation Intervention on Depressive Symptoms
     Alexa Stuifbergen, RN, PhD, FAAN
   • Imaging Cognitive Fatigue in Multiple Sclerosis: A Preliminary Quantification of Global Cerebral Blood Flow Using ASL Perfusion fMRI
     Lisa Walker, PhD
   • Cognitive Behavioral Therapy for Insomnia to Address Insomnia Symptoms in Individuals with Multiple Sclerosis
     Catherine Siengsukon, PT, PhD
     This speaker has opted not to publish this presentation.
   • Effects of Dual Tasking on the Neural Control System Underlying Mobility in Adults with Multiple Sclerosis
     Susan Kasser, PhD
   • Short-and Long-Term Impact of Mindfulness-Based Stress Reduction for People with MS: A Randomized Clinical Trial
     Angela Senders, ND, MCR
   • Physical and Mental Health Outcomes Following Unemployment: A Preliminary Report
     Lauren Strober, PhD
8. The Science and Art of Behavioral Medicine (all presenters)
   Amy Sullivan, PsyD, ABPP, Chair
   • Intro and In Vivo Patient Experience
     Amy Sullivan, PsyD, ABPP
   • Building the Patient Case
     Claire Hara-Cleaver, RN, MSN, ANP, CS
   • Understanding the MS Brain Pathway and Correlation to Depression
     Morgan Faeder, MD, PhD
   • Pharmacology of Mood Disorders
     Morgan Faeder, MD, PhD
   • Skills Building and Practice of Communication
     Panel
9. Primary Care Needs through the Spectrum of MS
   Marijean Buhse, PhD, RN, NP-C, MSCN, Chair
   • Erikson’s Theory of Psychological Development
     Marijean Buhse, PhD, RN, NP-C, MSCN
   • Children and Young Adults with MS: Striking a Balance between Medical and Psychosocial Needs
     Lauren Krupp, MD
   • Primary Care Needs and Social Implications of MS in the Early and Middle Aged Adult
     Patricia Melville, NP, MSCN
   • Keeping Well Despite MS: The Older Person with MS
     Marijean Buhse, PhD, MP-C, MSCNl
10. Pre-conception, Pregnancy and Post-partum Care of MS Patients: Clinical and Research Considerations
    A. Dessa Sadovnick, PhD, Chair
    • Introduction
      A. Dessa Sadovnick, PhD
    • Managing Women with MS: Conception, Gestation, Post-Partum
      Maria Houtchens, MD, MMsci
      This speaker has opted not to publish this presentation.
    • Pregnancy & Pregnancy Outcomes for Women with NMOSD
      Eric C. Klawiter, MD
    • The Importance of a Disease Specific Registry on Reproduction
      A. Dessa Sadovnick, PhD
11. Suicide in MS – from a Research, Clinical and Personal Perspective
    Rosalind Kalb, PhD, Chair
    • Suicide in MS: What the Numbers Tell Us
      Rosalind Kalb, PhD
    • Experience in the Clinic: Identifying and Helping Patients at Risk
      Mary Alissa Willis, MD

1. Facilitating Respiratory Enhancement in MS
   Donna Fry, PT, PhD, CHC; Marissa Barrera, MS, MPhil, MSCS, CCC-SLP, PhD
   • Presentation
   • Handout
2. Presidential Lecture: Neurorehabilitation in MS: Past, Present, Future
   Alan Thompson, MD, FRCP, FA-cadMedSci
3. Current Topics and Trends in MS Rehabilitation: Part I
   Patricia Bobryk, MHS, PT, MSCS, ATP, Moderator
   • Differential Diagnosis and Plan of Care of Imbalance in MS
     Susan Bennett, PT, DPT, EdD, NCS, MSCS; Lacey Bromley, PT, DPT, NCS, MSCS
4. Cognitive Dysfunction and Rehabilitation Techniques
   John DeLuca, PhD, Chair
   • Cognition and Cognitive Rehabilitation in MS: An Overview
     John DeLuca, PhD
   • Principles of Cognitive Rehabilitation: Application Through Clinical Trials in MS
     Yael Goverover, PhD
   • Theory-based Techniques in Memory Rehabilitation: Overview of Two Encoding-based Treatments
     Erica Weber, PhD
5. Current Topics and Trends in MS Rehabilitation: Part II
   Patricia Bobryk, MHS, PT, MSCS, ATP, Moderator
   • Orthotics for the Non Orthotist: How to Recommend the Proper Device
     Matt Sutliff, PT, DPT, MSCS
     • Presentation
     • Chart Handout
     • Algorithm Handout
   • Addressing the Challenges of MS-Related Visual Impairment
     Diane B. Whitaker, OD
6. Fundamentals of MS Care: Part II
   Multidisciplinary Approach to Symptom Management
   Beverly Layton, RN, BSN, CCRC, MSCN, Moderator
   • Managing Pain and Sensory Symptoms
     Marie Moore, MSN, ARNP, MSCN
   • Managing Sleep Disorders
     David Brandes, MS, MD, FAAN, MSC
   • Managing Symptoms of Elimination
     Marie Namey, RN, MS, MSCN
   • Effects of MS on Menopause, Pregnancy, and Sexual Function
     Patricia K. Coyle, MD
7. Current Topics and Trends in MS Rehabilitation: Part III
   Patricia Bobryk, MHS, PT, MSCS, ATP, Moderator
   • High Tech and Low Tech Applications for MS Issues – Thinking Outside of the Box
     Carolyn Phillips, MEd, ATP
   • Treatments Focusing on Mind-Body Understanding
     Staffan Elgelid, PT, PhD, FACRM
8. Comprehensive Care in Advanced MS
   Rachael Stacom, MS, ANP-BC, MSCN
   • Living with Advanced MS: An Approach to Patient-centered Care
     Rachael Stacom, MS, ANP-BC, MSCN
   • Symptom Management Strategies to Relieve Suffering in Advanced MS
     Stephen Krieger, MD
   • Using Adaptive Equipment and Assistive Technology to Maximize Function in Advanced MS
     Elaine Castelluccio, PT, MPT, MSCS
   • Empowering the Individual with a Cognitive Impairment and their Care Partners to Maximize Choice, Independence and Quality of Life
     Nettie Harper, CTRS
9. Obesity, Vascular Disease Risk Factors and MS: Impact, Current Management and Future Directions
   This session was developed with support from the VA MS Centers of Excellence
   Jodie K. Haselkorn, MD, MPH, Chair
   • Obesity and Vascular Disease Risk Factors in MS – Impact and Patient Management: Current State and Clinical Perspective
     Vijayshree Yadav, MD, MCR, FANA
     This speaker has opted not to publish this presentation.
   • Caloric Restriction and Inflammation in MS: Diet, Gut Microbiome, and Inflammation Emerging Relationship
     Michael Lane, MD
     This speaker has opted not to publish this presentation.
   • Obesity and Vascular Disease Risk Factors – Lessons and New Directions from Endocrinologist’s Perspective in Optimal Patient Management
     Jonathan Q. Purnell, MD
10. Summary of the 7th International Symposium on Gait and Balance in MS: Neuroplasticity and Rehabilitation in MS (all presenters)
    Michelle H. Cameron, MD, PT, MCR, Co-Chair; Kathleen Zackowski, PhD, OTR, MSCS, Co-Chair 
    • Neuroplasticity – The Foundation of Rehabilitation
      Michelle H. Cameron, MD, PT, MCR
    • Measuring Neuroplasticity – Imaging and Functional Measures
      Kathleen Zackowski, PhD, OTR, MSCS
    • Clinical Application and Implications of Neuroplasticity in Rehabilitation
      Kyle Eveland-DeWan, PTl
11. PLATFORM PRESENTATIONS: Rehabilitation
    • Continuous Remote Assessment of Multiple Sclerosis Disability over One Year: The UCSF Fitrims Study
      Valerie Block, PT, DPTSc
      This speaker has opted not to publish this presentation.
    • Inpatient Multidisciplinary Rehabilitation: Long-Term Effectiveness on Health-Related Quality of Life in MS Patients. – the Danish MS Hospitals Rehabilitation
      Michael Norgaard, MSc
    • Usability of the Atomic (Active Teens Multiple Sclerosis) Mobile App to Increase Physical Activity in Pediatric Multiple Sclerosis
      Samantha Stephens, PhD
    • Maximal Strength Training in MS: Effects on Mobility Deficits
      Herb Karpatkin, PT, DSc, NCS, MSCS
    • Correlation of Patient Report of Speech and Swallowing Difficulty with Diadochokinetic Rate
      Lori Kostich, MS CCC-SLP, MSCS
12. Current Topics and Trends in MS Rehabilitation: Part IV
    Rehabilitation Approaches to Improve Health, Function and Safety in People with Severe MS (all presenters)  
    Patricia Bobryk, MHS, PT, MSCS, ATP, Moderator
    • Introduction: Rationale for Including Rehabilitation in a Comprehensive Model of Care for People with Severe MS
      Deborah Backus, PT, PhD, FACRM, Chair
    • Muscle as a Target of Intervention in People with MS Joy Williams, PT, DPT
      FES Cycling Interventions for People with Significant Mobility Deficits
      Joy Williams, PT, DPT
    • Training Like an Astronaut: Use of the Anti-Gravity Treadmill to Improve Walking Capacity and Quality in People with Severe MS
      Deborah Backus, PT, PhD, FACRM
    • The Silent Disability: Cognitive Rehabilitation Strategies for People with Severe MS
      Bonnie Schaude, M.A. CCC-SLP
    • Exercise & Wellness Program for People with Severe MS
      Ian Flannery, PT, DPT
    • MS Boot Camp: A Comprehensive Day Program
      Ian Flannery, PT, DPT

1. John F. Kurtzke Memorial Lecture:
   Computerized Screening for Cognitive Dysfunction in the MS Clinic
   Stephen M. Rao, PhD
2. John Whitaker Research Track Platform Presentations
   Michael K. Racke, MD, Chair
   • Metabolomics Analysis Identifies Abnormal Bile Acid Metabolism in Multiple Sclerosis
     Leah Mische, BS
   • Variations within a 255,348 Base-Pair Region of Chromosome 1 That Show Association with Serum Prolactin Levels or MS Status
     Samantha Jack, MS
   • Acute Effects of High-Intensity Interval Exercise on Mood and Enjoyment Outcomes in Multiple Sclerosis
     Elizabeth Hubbard, PhD
   • Engaging the MS Community on Exercise Services for Those Living in Rural Australia
     Yvonne Learmonth, PhD
3. An MS Health Professional’s Guide to Cannabis
   Allen Bowling, MD, PhD
4. Real World Risks of Complex Therapies
   Joseph Berger, MD; Eric Williamson, MD
   • Infections, Malignancies and Other Risks with Newer Disease Modifying Therapy
   • PML and Disease Modifying Therapies
   • Infections other than PML with Disease Modifying Therapies
   • Risk of Malignancy
5. DMTs – What Does the Future Hold in MS Treatment?
   Fred D. Lublin, MD, Chair
   • Hx of Rx (MRI, BSeron, Safety, Orals, High Efficacy)
     Fred D. Lublin, MD
   • Future of Current DMTs – Expanded Use, Peds, New Uses
     Andrew D. Goodman, MD
   • MS DMT Pipeline New Approaches
     Ilana Katz Sand, MD
   • Protection, Repair and Regeneration
     Robert P. Lisak, MD, FRCP(E), FAAN, FANA
6. Regulation of CNS Inflammation 
   Francisco Quintana, PhD, Co-Chair; Ari Waisman, PhD, Co-Chair
   • Regulation of CNS Inflammation
     Francisco Quintana, PhD
   • Control of Immunopathology in CNS Autoimmunity
     Thomas Korn, MD
     This speaker has opted not to publish this presentation.
   • Role of Hyper-Activated Neutrophils in Autoimmune Neuroinflammation
     Etty (Tika) Benveniste, PhD
   • Mechanisms That Regulate the Pathogenic Functions of T Cells
     Estelle Bettelli, PhD
     This speaker has opted not to publish this presentation.
   • Cytokine Regulation of CNS Inflammation
     Ari Waisman, PhD
   • Dysregulated Immune Communication Can Cause Neuroinflammation
     Burkhard Becher, PhD
   • Targeting Phosphodiesterase-8 (PDE8) Controls Autoimmune CNS Inflammation by Mechanisms Distinct from PDE4 Inhibition
     Stefan Brocke, MD
   • Myeloperoxidase as a Therapeutic Target in Multiple Sclerosis
     Bonnie Dittel, PhD
7. Stem Cells for MS: An Update
   Mark Freedman, MD, Chair
   • Introduction
     Mark Freedman, MD
   • Haematopoietic Stem Cells for Resetting the Immune System Following Immunoablation
     Harry Atkins, MD, FRCP(C)
   • The Biological Basis for Using Mesenchymal Stem Cells to Treat MS
     Antonio Uccelli, MD
   • MSCs – Variables which Affect Outcomes
     Jacques Galipeau, MD, FRCP(C)
   • Science Hype and Marketing of Unproven Stem Cell Therapies
     Timothy Caulfield, LLM, FRSC, FCAHS
     This speaker has opted not to publish this presentation.
8. Blocking Lipid Metabolism in MS – A New Class of Medications
   John Nieland, PhD, Chair
   • New Ways of Looking at MS: A Systemic Disease
     John Nieland, PhD
   • Beyond Fats: Predicting Disease Onset and Relapse using Machine Learning Identification of Metabolic Markers
     Angelique Corthals, PhD
   • The Role of Dysregulated Lipid Metabolism in an EAE Model of Mice Mimicking the Inuit CPT1a Mutation
     Anne Skottrup Morkholt, PhD
   • Is There a Difference for the Role of Lipid Metabolism in Multiple Sclerosis, Parkinson’s Disease and Amyotrophic Lateral Sclerosis?
     Michael Sloth Trabjerg, MD, PhD student
9. Using Big Data: Prevalence and Morbidity Outcomes
   This session was developed with support from the VA MS Centers of Excellence
   Mitchell T. Wallin, MD, MPH, William J. Culpepper, II, PhD, MA
10. Pre-conception, Pregnancy and Post-partum Care of MS Patients: Clinical and Research Considerations
    A. Dessa Sadovnick, PhD, Chair
    • Introduction
      A. Dessa Sadovnick, PhD
    • Managing Women with MS: Conception, Gestation, Post-Partum
      Maria Houtchens, MD, MMsci
      This speaker has opted not to publish this presentation.
    • Pregnancy & Pregnancy Outcomes for Women with NMOSD
      Eric C. Klawiter, MD
    • The Importance of a Disease Specific Registry on Reproduction
      A. Dessa Sadovnick, PhD
11. Evaluating Clinical Trial Participation: What to Know
    Andrew D. Goodman, MD, Chair
    • PI Responsibilities
      Andrew D. Goodman, MD
    • Time is Money
      Cynthia J. Irish, RN, MSN, CCRC
    • Who, When and Where
      Nidhiben Anadani, MBBS

1. Addressing Provider Burnout Through the Use of Relationship Centered Care and Communication: An Interactive and Experientially Driven Program (all presenters)
   Matthew Sacco, PhD, Chair
   • What Do We Know About Professional Burnout & How to Combat It?
     Matthew Sacco, PhD
   • How Can Relationship-centered Communication Be Part of the Solution?
     Samantha Domingo, PsyD
   • How Can Relationship-centered Teaming be Part of the Solution?
     Amy Windover, PhD
   • Panel Q&A/Discussion: How to Incorporate RCC/Exercises/Interventions into their Respective Environments
     Matthew Sacco, PhD; Samantha Domingo, PsyD; Amy Windover, PhD; Lael Stone, MD
2. The Science and Art of Behavioral Medicine (all presenters)
   Amy Sullivan, PsyD, ABPP, Chair
   • Intro and In Vivo Patient Experience
     Amy Sullivan, PsyD, ABPP
   • Building the Patient Case
     Claire Hara-Cleaver, RN, MSN, ANP, CS
   • Understanding the MS Brain Pathway and Correlation to Depression
     Morgan Faeder, MD, PhD
   • Pharmacology of Mood Disorders
     Morgan Faeder, MD, PhD
   • Skills Building and Practice of Communication
     Panel
3. Use of Digital Tools for Patient Self-Management and Monitoring: 10 Years in, What Have We Learned?-Part 1
   Riley Bove, MD, Chair
   • From Information Seekers to Informants: The Rise of Online and Smartphone Tools to Collect and Disseminate MS Research – Which Tools to Use?
     Riley Bove, MD
     This speaker has opted not to publish this presentation.
   • Stepping It Up: Measuring and Increasing Activity Across the MS Ability Spectrum
     Valerie Block, PT, DPTSc
     This speaker has opted not to publish this presentation.
   • Taking the Full Measure of the Mind: From Measuring to Improving Mental Health
     Adam Kaplin, MD, PhD
   • Using Telehealth Tools to Increase Access and Reduce Barriers To Care
     Riley Bove, MD
     This speaker has opted not to publish this presentation.
4. Using Big Data: Prevalence and Morbidity Outcomes
   This session was developed with support from the VA MS Centers of Excellence
   Mitchell T. Wallin, MD, MPH, William J. Culpepper, II, PhD, MA
5. Suicide in MS – from a Research, Clinical and Personal Perspective
   Rosalind Kalb, PhD, Chair
   • Suicide in MS: What the Numbers Tell Us
     Rosalind Kalb, PhD
   • Experience in the Clinic: Identifying and Helping Patients at Risk
     Mary Alissa Willis, MD

1. Effective Assessment and Management Strategies for Complex Symptoms of MS
   Kathleen Costello, MS, ANP-BC, MSCN, Chair
   • Welcome and Introductions
     Kathleen Costello, MS, ANP-BC, MSCN
   • Complex Disorders of Mood Associated with MS: Assessment and Management
     Adam Kaplin, MD, PhD
   • Complex Mobility Issues in MS: Assessment and Management
     Susan Bennett, PhD, DPT, EdD, NCS, MSCS
   • Complex Visual Symptoms Associated with MS: Assessment and Management
     Robert K. Shin, MD
2. Fundamentals of MS Care: Part II
   Multidisciplinary Approach to Symptom Management
   Beverly Layton, RN, BSN, CCRC, MSCN, Moderator
   • Managing Pain and Sensory Symptoms
     Marie Moore, MSN, ARNP, MSCN
   • Managing Sleep Disorders
     David Brandes, MS, MD, FAAN, MSC
   • Managing Symptoms of Elimination
     Marie Namey, RN, MS, MSCN
   • Effects of MS on Menopause, Pregnancy, and Sexual Function
     Patricia K. Coyle, MD
3. Comprehensive Care in Advanced MS
   Rachael Stacom, MS, ANP-BC, MSCN
   • Living with Advanced MS: An Approach to Patient-centered Care
     Rachael Stacom, MS, ANP-BC, MSCN
   • Symptom Management Strategies to Relieve Suffering in Advanced MS
     Stephen Krieger, MD
   • Using Adaptive Equipment and Assistive Technology to Maximize Function in Advanced MS
     Elaine Castelluccio, PT, MPT, MSCS
   • Empowering the Individual with a Cognitive Impairment and their Care Partners to Maximize Choice, Independence and Quality of Life
     Nettie Harper, CTRS
4. PLATFORM PRESENTATIONS: Disease Assessment and Management
   • Clinical Cannabis Interprofessional Education: Program Development and Provider Knowledge
     Kim Jones, PhD
   • Optimal Inter-Eye Difference Thresholds in Retinal Nerve Fiber Layer and Ganglion Cell Layer Thickness for Predicting a Unilateral Optic Nerve Lesion in Multiple Sclerosis
     Rachel Nolan, BA
   • Rationale and Design of the Traditional Versus Early Aggressive Therapy for MS (TREAT-MS) Trial
     Scott Newsome, DO
   • Derivation and Validation of a Predictive Model for 30-Day Readmission Risk in Patients with Multiple Sclerosis
     Kanika Sharma, MD
   • Myelin Signal Isolated MRI (siMRI): A Novel Technique to Quantify Myelin Integrity Reveals Loss of Brain Architectonics in Multiple Sclerosis
     Tatiana Wolfe, PhD
     This speaker has opted not to publish this presentation.
   • The North American Registry for Care and Research in Multiple Sclerosis
     Kottil Rammohan, MD
   • Obesity at Onset Impacts the Early Clinical Presentation of Multiple Sclerosis
     Farren Briggs, PhD, ScM
   • Pediatric-Onset Multiple Sclerosis Is Associated with Reduced Parental Health-Related Quality of Life and Family Functioning
     Julia O’Mahony, BSc
5. The Science and Art of Behavioral Medicine (all presenters)
   Amy Sullivan, PsyD, ABPP, Chair
   • Intro and In Vivo Patient Experience
     Amy Sullivan, PsyD, ABPP
   • Building the Patient Case
     Claire Hara-Cleaver, RN, MSN, ANP, CS
   • Understanding the MS Brain Pathway and Correlation to Depression
     Morgan Faeder, MD, PhD
   • Pharmacology of Mood Disorders
     Morgan Faeder, MD, PhD
   • Skills Building and Practice of Communication
     Panel
6. Pharmacology – Part 2
   Jacquelyn Bainbridge, PharmD, MSCS, Moderator
   • Hashing It Out: An Update On the Use of Cannabis Products
     Matthew J. Makelky, Sr., PharmD, MSCS
   • Dissecting a Robust Pipeline: What is Currently on the Horizon for Multiple Sclerosis Therapies and An Update on Current Disease Modifying Therapies
     Felecia Hart, PharmD, MSCS

Integrative Medicine and MS
Allen Bowling, MD, PhD, Chair

• Introduction: MS as a Lifestyle Disease, “Pearls” for Clinical Practice, and Research Update
  Allen Bowling, MD, PhD
• Comorbidity and MS—Opportunity Knocks? Insights from Linked Health Administrative and Clinical Data
  Helen Tremlett, PhD
• Dietary Modification and Multiple Sclerosis Course
  Kathryn Fitzgerald, ScD, ScM
• Mindfulness in Motion: A Multimodal Intervention Beneficial for Both Patient and Healthcare Provider
  Maryanna D. Klatt, PhD
  This speaker has opted not to publish this presentation.