Nature continues to show that our own body can produce cells that can modify and treat a variety of conditions, including autoimmune diseases like MS. Technology allows for the isolation, purification and modification of cells to exploit their various properties. In this session we will discuss various endeavors to produce cells that might replace those affected by MS, such as oligodendrocytes, or even neural cells. For many years, the ability to harvest purified stem cells to replenish a diseased or ablated immune system has afforded the use of transplantation as a treatment for aggressive disease or MS refractory to standard therapies. Finally the ability to modify immune cells by reforming T cell receptors (CAR-T) opens the door to more antigen specific therapies and the development of cells capable of crossing into the CNS to find their targets. Level of Information: AdvancedNature continues to show that our own body can produce cells that can modify and treat a variety of conditions, including autoimmune diseases like MS. Technology allows for the isolation, purification and modification of cells to exploit their various properties. In this session we will discuss various endeavors to produce cells that might replace those affected by MS, such as oligodendrocytes, or even neural cells. For many years, the ability to harvest purified stem cells to replenish a diseased or ablated immune system has afforded the use of transplantation as a treatment for aggressive disease or MS refractory to standard therapies. Finally the ability to modify immune cells by reforming T cell receptors (CAR-T) opens the door to more antigen specific therapies and the development of cells capable of crossing into the CNS to find their targets. Level of Information: Advanced