This session will explore emerging and high-impact developments shaping the future of multiple sclerosis (MS) care and research. Dr. Moein Amin will discuss the expanding role of artificial intelligence in MS, highlighting applications in diagnosis, imaging analysis, prognostication, and clinical decision support. Dr. Farrah J. Mateen will examine the evolving evidence surrounding GLP-1 agonists and related metabolic therapies, addressing their potential implications for MS disease activity, comorbidities, and patient outcomes. Dr. Ahmed Obeidat will focus on innovations in clinical trial design, challenging traditional paradigms and presenting strategies to improve efficiency, inclusivity, and real-world relevance in MS research. Together, these talks will provide a forward-looking perspective on how technological advances, novel therapeutic approaches, and reimagined research frameworks are converging to transform the MS landscape. Attendees will gain insight into cutting-edge concepts with practical implications for clinical care and future investigation. Level of Information: Intermediate; AdvancedThis session will explore emerging and high-impact developments shaping the future of multiple sclerosis (MS) care and research. Dr. Moein Amin will discuss the expanding role of artificial intelligence in MS, highlighting applications in diagnosis, imaging analysis, prognostication, and clinical decision support. Dr. Farrah J. Mateen will examine the evolving evidence surrounding GLP-1 agonists and related metabolic therapies, addressing their potential implications for MS disease activity, comorbidities, and patient outcomes. Dr. Ahmed Obeidat will focus on innovations in clinical trial design, challenging traditional paradigms and presenting strategies to improve efficiency, inclusivity, and real-world relevance in MS research. Together, these talks will provide a forward-looking perspective on how technological advances, novel therapeutic approaches, and reimagined research frameworks are converging to transform the MS landscape. Attendees will gain insight into cutting-edge concepts with practical implications for clinical care and future investigation. Level of Information: Intermediate; Advanced