The Role of Complement in MS

The Role of Complement in MS
Horea Rus, MD, PhD

RELEASE DATE: May 29, 2020

EXPIRATION DATE: May 31, 2021

TIME TO COMPLETE THE ACTIVITY: 1 hour

TARGET AUDIENCE
This activity has been designed to meet the educational needs of physicians, advanced practice clinicians, nursing professionals, pharmacists, psychologists, social workers, rehabilitation specialists, researchers, advocates, and other members of the healthcare team involved in the management of patients with MS, conduct research in MS or who have a special interest in MS.

LEARNING OBJECTIVES

  • Describe activation of the complement system and subsequent tissue damage which plays an important role in both inflammatory demyelination and neurodegeneration
  • Explain the neuroprotective effects of complement activation which show that the C5b-9 complement complex plays an important role in the repair process by limitation of glial scarring, remyelination, and protection of oligodendrocytes from cell death

ACCREDITATION AND CREDIT DESIGNATION
In support of improving patient care, the Consortium of Multiple Sclerosis Centers (CMSC) is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.

PHYSICIANS
The CMSC designates this enduring material for 1.0 AMA PRA Category 1 CreditsTM. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

NURSES
The CMSC designates this enduring material for 1.0 contact hour of continuing nursing education.

PHARMACISTS
This knowledge-based activity (UAN # JA4008165-0000-20-016-H01-P) qualifies for 1.0 contact hour (0.1 CEUs) of continuing pharmacy education credit.

PAs
The Consortium of Multiple Sclerosis Centers has been authorized by the American Academy of PAs (AAPA) to award AAPA Category 1 CME credit for activities planned in accordance with AAPA CME Criteria. This activity is designated for 1.0 AAPA Category 1 CME credits. Approval is valid until May 31, 2021. PAs should only claim credit commensurate with the extent of their participation.

CERTIFICATE OF ATTENDANCE FOR OTHER HEALTHCARE PROFESSIONALS
A Certificate of Attendance will be given upon completion of course requirements enabling attendees to register their credit with the appropriate licensing boards or associations. Attendees may apply for other accreditations using procedures established by specific organizations.

DISCLOSURE OF CONFLICTS OF INTEREST
It is the policy of CMSC to ensure balance, independence, objectivity, and scientific rigor in all educational activities. All faculty, planning committee members, content reviewers, and staff participating in this activity have disclosed any relevant financial relationships they or their significant other have had within the previous 12 months with manufacturers of any commercial products/devices and/or providers of commercial services included in this educational activity. The intent of this disclosure is not to prevent a person with a relevant financial relationship from participating in the activity, but rather to provide participants with information on which they can base their own judgments.  All presentations were reviewed by an independent clinician with no relevant financial relationships for the purpose of resolution of any identified conflict of interest and a determination of evidence-base and fair balance.

FACULTY DISCLOSURE
Horea Rus, MD, PhD has disclosed the following relevant financial relationships: Grants Support: Novartis, Biogen, Merck-Serono, and Mallinckrodt Pharma.

PLANNERS, REVIEWERS AND STAFF DISCLOSURES
Corey C. Ford, MD, PhD (Planner) has disclosed the following relevant financial relationship(s): Consulting Fee: Teva Pharmaceuticals, GW Pharma, and Actelion; Contracted Research: Actelion, Adamas, Alkermes, Biogen, Genentech, Genzyme, Mallinckrodt, Medday, Novartis, Roche, Sanofi Aventis, Teva Pharmaceuticals, and TG Therapeutics.

June Halper, MSN, APN-C, MSCN, FAAN (Planner and Reviewer) has disclosed no relevant financial relationships.

Colleen Harris, MN, NP, MSCN (Planner) has disclosed the following relevant financial relationship(s): Consulting Fee: Biogen, Roche, Merck, Sanofi Genzyme, and Novartis Pharmaceuticals Corp.

Laurie Scudder, DNP, NP (Reviewer) has disclosed no relevant financial relationships.

Tina Trott and the staff at CMSC have disclosed no relevant financial relationships.

FEE INFORMATION
There is no fee to participate in these educational activities.

INSTRUCTIONS FOR PARTICIPATION AND OBTAINING CREDIT
In order to successfully complete this knowledge-based continuing education activity, participants must:
1) Read the learning objectives and disclosures.

2) Study/view the educational content.

3) Complete the online evaluation form.

To complete the evaluation and claim credit, go to www.highmarksce.com/mscare/
1) Create a new account or log in with your user name and password*.

2) Select the Enduring Materials tab, select the activity from the list and follow the instructions to complete the activity and receive your credit.

*If you forgot your username or password, click on Forgot password. You will receive an email with a link to change your password.

For credit claiming assistance, please contact education@mscare.org .

COMPUTER SYSTEM REQUIREMENTS
It is recommended that you use the latest version of Microsoft Edge, Chrome, Safari, or Firefox to view this activity.

DISCLOSURE OF UNLABELED USE
CMSC requires faculty to disclose to the attendees when products or procedures being discussed are off-label, unlabeled, experimental, and/or investigational (not FDA approved); and any limitations on the information that is presented, such as data that are preliminary or that represent ongoing research, interim analyses, and/or unsupported opinion. Faculty in this activity may discuss information about pharmaceutical agents that is outside of US Food and Drug Administration approved labeling. This information is intended solely for continuing education and is not intended to promote off-label use of these medications. If you have questions, contact the medical affairs department of the manufacturer for the most recent prescribing information.

DISCLAIMER
CMSC presents this information for educational purposes only. The content is provided solely by faculty who have been selected because of recognized expertise in their field. Participants have the professional responsibility to ensure that products are prescribed and used appropriately on the basis of their own clinical judgment and accepted standards of care. CMSC assumes no liability for the information herein.

CONTACT INFORMATION
For information about the accreditation of this program, please contact the CMSC at education@mscare.org.

About Me

The Continuing Medical Education Program is an integral part of the organization’s overall mission which aims to improve learners’ competence and performance‐in‐practice and ultimately improve patient outcomes.

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