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Year ID Type Category Title Authors
2017 DX37 Poster Disease Modifying Therapy

Long-Term Outcomes for Subgroup of Patients with a Primary Presentation of Optic Neuritis in the TOPIC Extension Study

Jiwon Oh, MD1, Ludwig Kappos, MD2, Giancarlo Comi, MD3, Mark S Freedman, MD4, Jerome de Seze, MD5, Jerry S Wolinsky, MD6, Philippe Truffinet, MD7, Myriam Benamor, MD7, Karthinathan Thangavelu, PhD8 and Aaron E Miller, MD9, (1)St. Michael’s Hospital, University of Toronto, Toronto, ON, Canada, (2)University Hospital Basel, University of Basel, Basel, Switzerland, (3)University Vita-Salute San Raffaele, Milan, Italy, (4)University of Ottawa and the Ottawa Hospital Research Institute, Ottowa, ON, Canada, (5)University Hospital of Strasbourg, Strasbourg, France, (6)University of Texas Health Science Center at Houston, Houston, TX, (7)Sanofi Genzyme, Chilly-Mazarin, France, (8)Sanofi Genzyme, Cambridge, MA, (9)Corinne Goldsmith Dickinson Center for Multiple Sclerosis at Mount Sinai, New York, NY

2017 DX38 Poster Disease Modifying Therapy

Immunological Effects of Lithium in Progressive Multiple Sclerosis

John R Rinker II, MD, Neurology, Birmingham VA Medical Center, Birmingham, AL, Patrizia De Sarno, PhD, Neurology, University of Alabama at Birmingham, Birmingham, AL and Chander Raman, PhD, Medicine, University of Alabama at Birmingham, Birmingham, AL

2017 DX39 Poster Disease Modifying Therapy

Monthly 3T MRI in MS Patients Switched from Natalizumab to Teriflunomide in a Controlled, Prospective Study

Keith R Edwards, MD1, Stanley Cohan, MD, PhD2, Lore Garten, MD, Ph. D.1, James Thomas, M.D.3, Kyle E Smoot, MD2, Kiren Kresa-Reahl, MD2, Judy O’Connor, BSW, CCRC1, Tiffany Gervasi, Clinical Research Coordinator2, Chiayi Chen, Ph.D.2, Jessica Siuta, BSMT, ASCP, Clinical Research Coordinator1 and Vineetha Kamath, BS1, (1)MS Center of Northeastern New York, Latham, NY, (2)Providence Multiple Sclerosis Center, Portland, OR, (3)Radiology, Community Care Physicians, P.C., Latham, NY

2017 DX40 Poster Disease Modifying Therapy

Association Between Fingolimod and HPV-Related Complications in Women with MS

Kendra L Yale, MMS, PA-C, MSCS1, Kristin Stockman, MSN, ANP-BC, MSCS1 and Shannon Cornell, MSN, ANP-BC, MSCS2, (1)Neurology, University of Colorado, Aurora, CO, (2)University of Colorado, Aurora, CO

2017 DX41 Poster Disease Modifying Therapy

Rates of Comorbidities in Patients with and without Multiple Sclerosis: A US Retrospective Claims Database Analysis

Kiren Kresa-Reahl, MD1, Natalie C Edwards, MSc2, Gary Schneider, ScD3, Kevin Stern, BS3 and Amy L Phillips, PharmD4, (1)Providence MS Center, Portland, OR, (2)Health Services Consulting Corporation, Boxborough, MA, (3)Boston Health Economics, Inc., Waltham, MA, (4)EMD Serono, Inc., Rockland, MA

2017 DX42 Poster Disease Modifying Therapy

Microscopic Hematuria in Patients on Tecfidera

Kirstin Nygren, MSN, FNP-BC, MSCN and Barbara Giesser, MD, Neurology, UCLA, Los Angeles, CA

2017 DX43 Poster Disease Modifying Therapy

Natalizumab in Anti-JCV Antibody Negative Patients with Early RRMS: Prespecified Analysis of Optical Coherence Tomography (OCT) and Visual Acuity Data

Laura J Balcer, MD, MSCE1, Steven Galetta, MD1, Jai Perumal, MD2, Roumen Balabanov, MD3, Robert J Fox, MD, FAAN4, Qunming Dong, MD5, Shavy Makh, MPhil5, Christophe Hotermans, MD5, John S Walsh, MD5, Denise Campagnolo, MD6 and Lily Lee, MD5, (1)New York University Langone Medical Center, New York, NY, (2)Judith Jaffe Multiple Sclerosis Center, New York, NY, (3)Rush University Multiple Sclerosis Center, Chicago, IL, (4)The Mellen Center for Multiple Sclerosis Treatment and Research, Cleveland Clinic, Cleveland, OH, (5)Biogen, Cambridge, MA, (6)Formerly Biogen, Cambridge, MA

2017 DX44 Poster Disease Modifying Therapy

Infusion-Related Reactions with Ocrelizumab: Pooled Analysis of the Open-Label Extension of the Phase III, Interferon Beta-1a-Controlled OPERA Studies

Lori Mayer, DNP, MSN, RN1, Ludwig Kappos, MD2, Michael K Racke, MD3, Kottil Rammohan, MD4, Anthony Traboulsee, MD5, Jerry Wolinsky, MD6, Cathy Chognot, PhD7, Laura Julian, PhD8, Julie Napieralski, PhD7, Johan van Beek, PhD7, Hanzhe Zheng, PhD8 and Stephen L Hauser, MD9, (1)Central Texas Neurology Consultants, Multiple Sclerosis Clinic of Central Texas, Round Rock, TX, (2)University Hospital Basel, University of Basel, Basel, Switzerland, (3)Wexner Medical Center, Ohio State University, Columbus, OH, (4)University of Miami, Miami, FL, (5)University of British Columbia, Vancouver, BC, Canada, (6)McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX, (7)F. Hoffmann-La Roche Ltd, Basel, Switzerland, (8)Genentech Inc., South San Francisco, CA, (9)University of California, San Francisco, San Francisco, CA

2017 DX45 Poster Disease Modifying Therapy

The Emotional Impact of an Opportunistic Infection in Multiple Sclerosis Patients Treated with Highly Effective Therapies

Louise M Rath, RN, MA (Bioethics), Neurosciences, Alfred Health, Melbourne, Australia

2017 DX46 Poster Disease Modifying Therapy

Safety of Ocrelizumab in Multiple Sclerosis: Updated Analysis in Patients with Relapsing and Primary Progressive Multiple Sclerosis

2017 DX47 Poster Disease Modifying Therapy

Leukopenia in Multiple Sclerosis Patients on Peginterferon-B-1a

Malissa C Ayers, Physician Assistant, Mellen Center, Cleveland Clinic Foundation, Cleveland, OH and Mary A Willis, MD, Mellen Center, Cleveland Clinic, Cleveland, OH

2017 DX48 Poster Disease Modifying Therapy

Characteristics of Patients Switching to Subcutaneous Peginterferon Beta-1a Vs. Subcutaneous Interferon Beta-1a in the United States

Mehul Jhaveri, PharmD, MPH1, Ning Wu, PhD1, Crystal Watson, MS1, Kun Yang, PharmD2 and Daniel Jones, PhD2, (1)Biogen, Cambridge, MA, (2)Biogen, Weston, MA

2017 DX49 Poster Disease Modifying Therapy

Safety and Effectiveness of Delayed-Release Dimethyl Fumarate in a Canadian Cohort Enrolled in the ESTEEM Study

Konstantin Balashov, MD1, Richard Macdonell, MD2, Kathryn Giles, MD, MSc, FRCPC3, Nicholas Everage, PhD4, Claudia Prada, MD, PhD4, Katherine Riester, MPH4, Dane Cloutier, MSc5 and Mihaela Vlaicu, MD5, (1)Robert Wood Johnson Medical School, Rutgers University, New Brunswick, NJ, (2)Austin Health, University of Melbourne, Melbourne, Australia, (3)Cambridge Memorial Hospital, Cambridge, ON, Canada, (4)Biogen, Cambridge, MA, (5)Biogen, Mississauga, ON, Canada

2017 DX50 Poster Disease Modifying Therapy

Socio-Economic Disparity in Treatment and Healthcare Resource Use in Patients with Multiple Sclerosis Covered By Medicaid

Mitzi J Williams, MD1, Lilyana Amezcua, MD, MS2, Alexander Green, MD, MPH3, Hollie Schmidt, MS4, Jia Zhou, MS5, Qiang Hou, PhD5, Jaanai Babb, PharmD6, Jessica Royall, MBA6 and Terrie Livingston, PharmD6, (1)Multiple Sclerosis Center of Atlanta, Atlanta, GA, (2)Neurology, University of Southern California, Los Angeles, CA, (3)Division of General Internal Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, (4)Accelerated Cure Project for MS, Waltham, MA, (5)Biogen, Cambridge, MA, (6)Biogen, Weston, MA

2017 DX51 Poster Disease Modifying Therapy

JCV Antibody Sero-Conversion Ratio of RRMS Patients during and Regardless Natalizumab Therapy: A Single Centered Retrospective Survey

Nasima Afsari, MBBS, MPH, Neurology, Medstar Georgetown University Hospital, Washington DC, DC

2017 DX52 Poster Disease Modifying Therapy

Teriflunomide Real-World Outcomes from the US Cohort of the Phase 4 Teri-PRO Study

Patricia K Coyle, MD1, Bhupendra Khatri, MD2, Keith R Edwards, MD3, Steve Cavalier, MD4, Pascal Rufi, MD5, Karthinathan Thangavelu, PhD4, Myriam Benamor, MD5 and Ralf Gold, MD6, (1)Stony Brook University, Stony Brook, NY, (2)The Regional MS Center, Center for Neurological Disorders at Wheaton Franciscan Healthcare, Milwaukee, WI, (3)Multiple Sclerosis Center of Northeastern New York, Latham, NY, (4)Sanofi Genzyme, Cambridge, MA, (5)Sanofi Genzyme, Chilly-Mazarin, France, (6)St Josef Hospital, Ruhr University Bochum, Bochum, Germany

2017 DX53 Poster Disease Modifying Therapy

Using Acthar in Lemtrada Infusion Protocol

Patricia A Pagnotta, ARNP, MSN, MSCN, CCRN, Neurology Associates, PA, Maitland, FL, Christopher LaGanke, MD, North Central Neurology Associates, Cullman, AL and Constance B Easterling, RN, MSN, ANP, MSCN, Multiple Sclerosis Care Center of Neurological Services, Hackensack, NJ

2017 DX54 Poster Disease Modifying Therapy

Perceptions Regarding the FDA Approval of MS Therapies

Paul Ford, Ph.D.1, Stacey S Cofield, PhD2, Tuula Tyry, PhD3, Carol Cosenza, MSW4, Amber Salter, PhD5, Mary Beth Mercer, MPH1, Sneha Natarajan, PhD6, Lauren Cripps, MA4, Gary Cutter, PhD7 and Robert J Fox, MD, FAAN6, (1)Bioethics, Cleveland Clinic, Cleveland, OH, (2)Biostatistics, University of Alabama at Birmingham, Birmingham, AL, (3)Dignity Health, St. Joseph’s Hospital and Medical Center, Phoenix, AZ, (4)Center for Survey Research, University of Massachusetts, Boston, Boston, MA, (5)Biostatistics, Washington University in St. Louis, St. Louis, MO, (6)The Mellen Center for Multiple Sclerosis Treatment and Research, Cleveland Clinic, Cleveland, OH, (7)University of Alabama at Birmingham, Birmingham, AL

2017 DX55 Poster Disease Modifying Therapy

Short- and Long-Term Predictors of Relapse or Disability Worsening in Patients with Multiple Sclerosis in the Phase 3 FREEDOMS and FREEDOMS II Studies

Aaron Boster, MD1, Pavle Repovic, MD, PhD2, Shannon Ritter, MS3, Davorka Tomic, PhD4, Xiangyi Meng, PhD3, Daniela P Meier, MD4, Fernanda Boulos, MD3, Frederik Barkhof, MD, PhD5 and Till Sprenger, MD6, (1)Ohio State University, Columbus, OH, (2)Multiple Sclerosis Center, Swedish Neuroscience Institute, Seattle, WA, (3)Novartis Pharmaceuticals Corporation, East Hanover, NJ, (4)Novartis Pharma AG, Basel, Switzerland, (5)Department of Radiology & Nuclear Medicine, VU University Medical Center, Amsterdam, Netherlands, (6)Medical Image Analysis Center and Department of Neurology, University Hospital Basel, Basel, Switzerland

2017 DX56 Poster Disease Modifying Therapy

Short- and Long-Term Predictors of Relapses or Disability Worsening in Patients with Multiple Sclerosis in the Phase 3 TRANSFORMS Study

Aaron Boster, MD1, Pavle Repovic, MD, PhD2, Xiangyi Meng, PhD3, Daniela P Meier, MD4, Fernanda Boulos, MD3, Till Sprenger, MD5 and Frederik Barkhof, MD, PhD6, (1)Ohio State University, Columbus, OH, (2)Multiple Sclerosis Center, Swedish Neuroscience Institute, Seattle, WA, (3)Novartis Pharmaceuticals Corporation, East Hanover, NJ, (4)Novartis Pharma AG, Basel, Switzerland, (5)Medical Image Analysis Center and Department of Neurology, University Hospital Basel, Basel, Switzerland, (6)Department of Radiology and Nuclear Medicine, VU University Medical Center, Amsterdam, Netherlands

2017 DX57 Poster Disease Modifying Therapy

Improved Processing Speed on Fingolimod Therapy: Oral Symbol Digit Modalities Test Response in PREFERMS

Ralph HB Benedict, PhD1, Douglas L Arnold, MD2,3, Bruce AC Cree, MD4, Xiangyi Meng, PhD5, Lesley Schofield, PhD5, Fernanda Boulos, MD5 and Nadia Tenenbaum, MD5, (1)University at Buffalo, State University of New York, Buffalo, NY, (2)NeuroRx Research, Montreal, QC, Canada, (3)McGill University, Montreal, QC, Canada, (4)Multiple Sclerosis Center, San Francisco, CA, (5)Novartis Pharmaceuticals Corporation, East Hanover, NJ

2017 DX58 Poster Disease Modifying Therapy

Post Hoc Analysis of PRISMS Study: Efficacy of Interferon beta-1a Subcutaneously Three Times Weekly According to Baseline EDSS/Duration, EDSS, and MSSS Subgroups

Regina Berkovich, MD1, Hao Zhang, PhD2, Julie Aldridge, MS2, Scott Baver, PhD3 and Eric Williamson, MD4, (1)University of Southern California, Los Angeles, CA, (2)EMD Serono, Inc., Billerica, MA, (3)EMD Serono, Inc., Rockland, MA, (4)University of Pennsylvania Penn Neuroscience Center, Philadelphia, PA

2017 DX59 Poster Disease Modifying Therapy

Efficacy and Safety of Teriflunomide in Asian Patients with Relapsing Forms of MS: A Subgroup Analysis of the Phase 3 TOWER Study

Richard Macdonell, MD1, Mark S Freedman, MD2, Xianhao Xu, MD3, Steve Vucic, MD4, Philippe Truffinet, MD5, Myriam Benamor, MD5, Karthinathan Thangavelu, PhD6 and Aaron E Miller, MD7, (1)Austin Health, Heidelberg, Australia, (2)University of Ottawa and the Ottawa Hospital Research Institute, Ottowa, ON, Canada, (3)Beijing Hospital, Beijing, China, (4)University of Sydney, Sydney, Australia, (5)Sanofi Genzyme, Chilly-Mazarin, France, (6)Sanofi Genzyme, Cambridge, MA, (7)Corinne Goldsmith Dickinson Center for Multiple Sclerosis at Mount Sinai, New York, NY

2017 DX60 Poster Disease Modifying Therapy

EVOLVE-MS-2: Randomized, Double-blind Phase 3 Study of Gastrointestinal Tolerability for ALKS 8700 Versus Dimethyl Fumarate in Relapsing-Remitting Multiple Sclerosis

Robert T Naismith, MD1, Richard A Leigh-Pemberton, MD2, Amy E Claxton, PhD2, Marjie L Hard, Ph.D.2, Yangchun Du, PhD2, Lisa von Moltke, MD2, Anthony J Lembo, MD3 and Jerry Wolinsky, MD4, (1)Neurology, Washington University School of Medicine, St Louis, MO, (2)Alkermes, Inc., Waltham, MA, (3)Beth Israel Deaconess Medical Center, Boston, MA, (4)University of Texas Health Science Center at Houston, Houston, TX

2017 DX61 Poster Disease Modifying Therapy

Effect of Teriflunomide on Cortical Atrophy in a Subgroup Analysis of Patients Presenting with Optic Neuritis in the Phase 3 TOPIC Study

Robert Zivadinov, MD1, Michael G Dwyer, PhD1, Ellen Carl, PhD1, Karthinathan Thangavelu, PhD2, Steve Cavalier, MD2 and Niels Bergsland, PhD1, (1)University at Buffalo, Buffalo, NY, (2)Sanofi Genzyme, Cambridge, MA

2017 DX63 Poster Disease Modifying Therapy

Effects of DMTs on Lymphocytes and Infections

Salvatore Q Napoli, MD and Sarah B Cardoso, Research Coordinator, Neurology Center of New England P.C., Foxboro, MA

2017 DX64 Poster Disease Modifying Therapy

Fatal CNS Hemorrhage in a Patient with Relapsing-Remitting MS Who Received Alemtuzumab

Samuel F Hunter, MD, PhD1, David H Margolin, MD, PhD2, Kastytis Sestakauskas, MD3, James Thomas, MD2, Claudio E Rodriguez, MD2, Vladimir Evilevitch, MD2 and Alan K Jacobs, MD2, (1)Advanced Neurosciences Institute, Franklin, TN, (2)Sanofi Genzyme, Cambridge, MA, (3)Sanofi Research & Development, Chilly-Mazarin, France

2017 DX65 Poster Disease Modifying Therapy

Real-World, Individualized, Comprehensive Patient Education and Support Procedures to Optimize Treatment Experience with Alemtuzumab

Santrina Fletcher, RN, MSN, CNP1, Rhonda Cortright, MSCS1, Mary Pat Bartoszek, CNP, MSCN2 and Colleen E Miller, DNS2, (1)Riverhills Neuroscience, Cincinnati, OH, (2)Sanofi Genzyme, Cambridge, MA

2017 DX66 Poster Disease Modifying Therapy

Interferon Associated Retinopathy in a Patient with Relapsing Remitting Multiple Sclerosis

Sara Razmjou, MD, M.Sc, Maziar Eslami Farsani, MD, Sheridan Reed, BS, Samuel Lichtman-Mikol, BA, Navid Seraji-Bozorgzad, MD, M.Sc and Evanthia Bernitsas, MD, Neurology, Wayne State School of Medicine, Detroit, MI

2017 DX67 Poster Disease Modifying Therapy

Pregnancy Outcomes Following Ocrelizumab Treatment in Patients with Multiple Sclerosis and Other Autoimmune Diseases

Sibyl Wray, MD1, Silvia Bader-Weder, MD2, Regine Buffels, MD2, Donna Masterman, MD, MS3, Julie Napieralski, PhD2 and Stephen L Hauser, MD4, (1)Hope Neurology MS Center, Knoxville, TN, (2)F. Hoffmann-La Roche Ltd, Basel, Switzerland, (3)Genentech Inc., South San Francisco, CA, (4)University of California, San Francisco, San Francisco, CA

2017 DX68 Poster Disease Modifying Therapy

Cladribine Tablets in the Treatment of Patients with Multiple Sclerosis: An Integrated Analysis of Infections in Association with Severe Lymphopenia

Stuart Cook, MD1, Thomas Leist, MD2, Giancarlo Comi, MD3, Xavier Montalban, MD4, Elke Sylvester, MD5, Christine Hicking, MS5 and Fernando Dangond, MD6, (1)Rutgers, The State University of New Jersey, Newark, NJ, (2)Thomas Jefferson University, Philadelphia, PA, (3)University Vita-Salute San Raffaele, Milan, Italy, (4)Hospital Universitari Vall d’Hebron, Barcelona, Spain, (5)Merck KGaA, Darmstadt, Germany, (6)EMD Serono, Inc., Billerica, MA

2017 DX69 Poster Disease Modifying Therapy

Cladribine Tablets in the Treatment of Patients with Multiple Sclerosis: An Integrated Analysis of Safety from the Multiple Sclerosis Clinical Development Program

Stuart Cook, MD1, Thomas Leist, MD2, Giancarlo Comi, MD3, Xavier Montalban, MD4, Elke Sylvester, MD5, Christine Hicking, MS5 and Fernando Dangond, MD6, (1)Rutgers, The State University of New Jersey, Newark, NJ, (2)Thomas Jefferson University, Philadelphia, PA, (3)University Vita-Salute San Raffaele, Milan, Italy, (4)Hospital Universitari Vall d’Hebron, Barcelona, Spain, (5)Merck KGaA, Darmstadt, Germany, (6)EMD Serono, Inc., Billerica, MA

2017 DX70 Poster Disease Modifying Therapy

Online Education Improves Neurologists’ Knowledge of Investigational Therapies for the Treatment of Multiple Sclerosis

Thomas Finnegan, PhD, Medscape LLC, New York, NY, Gena Dolson, MS, Medscape Education, New York, NY and Stephen Krieger, MD, Icahn School of Medicine, Corinne Goldsmith Dickinson Center for Multiple Sclerosis, New York, NY

2017 DX71 Poster Disease Modifying Therapy

Reduction of Lymphopenia by Cladribine Tablets Under Retreatment Guidelines: A Long-Term Follow-Up Analysis of Patients in the ORACLE-MS Study

Thomas Leist, MD1, Giancarlo Comi, MD2, Mark S Freedman, MD3, Bruce AC Cree, MD4, Patricia K Coyle, MD5, Hans-Peter Hartung, MD6, Patrick Vermersch, MD7, Elke Sylvester, MD8, Doris Damian, PhD9 and Fernando Dangond, MD9, (1)Thomas Jefferson University, Philadelphia, PA, (2)University Vita-Salute San Raffaele, Milan, Italy, (3)University of Ottawa and the Ottawa Hospital Research Institute, Ottowa, ON, Canada, (4)Multiple Sclerosis Center, San Francisco, CA, (5)Stony Brook University, Stony Brook, NY, (6)Heinrich Heine University, Dusseldorf, Germany, (7)Univ. Lille, CHU Lille, LIRIC – INSERM U995, Lille, France, (8)Merck KGaA, Darmstadt, Germany, (9)EMD Serono, Inc., Billerica, MA

2017 EG01 Poster Epidemiology and Genetics

Epidemiological Profile of Patients with Multiple Sclerosis

2017 EG02 Poster Epidemiology and Genetics

Pediatric Symptom Onset of Multiple Sclerosis in Hispanic Patients

Angel Chinea, MD1, Ivonne Vicente, MD2, Cristina M Rubi, BS2, Guillermo G Garcia, BS3, Astrid Diaz, BS3, Ana Rivera, BS3 and Natalia Hernandez, BS3, (1)San Juan Multiple Sclerosis Center, San Juan, PR, (2)San Juan Multiple Sclerosis Center, Guaynabo, PR, (3)San Juan MS Center, Guaynabo, PR

2017 EG03 Poster Epidemiology and Genetics

Benefits of Having an MS Registry Enforced By a Law

Angel Chinea, MD1, Ivonne Vicente, MD2, Cristina M Rubi, BS2, Guillermo G Garcia, BS3, Astrid Diaz, BS3, Natalia Hernandez, BS3 and Ana Rivera, BS3, (1)San Juan Multiple Sclerosis Center, San Juan, PR, (2)San Juan Multiple Sclerosis Center, Guaynabo, PR, (3)San Juan MS Center, Guaynabo, PR

2017 EG04 Poster Epidemiology and Genetics

Puberty Onset and Pediatric Multiple Sclerosis Activity in Boys

Brenda Young, BS1, Emmanuelle Waubant, MD, PhD2, Sabeen Lulu, MD2 and Jennifer Graves, MD, PhD, MAS3, (1)San Francisco, CA, (2)UCSF Pediatric MS Center, San Francisco, CA, (3)University of California, San Francisco, San Francisco, CA

2017 EG05 Poster Epidemiology and Genetics

PML Dedicated Clinical Data Collection: An Industry Perspective

Christine Nelson, PharmD, RPh, Kerry McCarthy, BSN, Shawn Burke, PharmD, RPh, Peishan Liu Snyder, PhD and Sarah Buckley, BSN, Biogen, Cambridge, MA

2017 EG06 Poster Epidemiology and Genetics

Multiple Sclerosis Burden of Illness in the Hawaiian Islands: Ethnic Comparison of Hospitalization Cost and Utilization

Alden R. Smith, PharmD1, Lobat Hashemi, ScD1, Frank Ragone, PhD1 and Deborah A Taira, ScD2, (1)Sanofi Genzyme, Cambridge, MA, (2)University of Hawaii, Hilo, HI