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Presidential Lecture: Aging in MS
Lecturer: Jennifer Graves, MD, PhD, MAS (UCSD)
The most significant driving factor of multiple sclerosis phenotype is age. Chronological age is associated with relapse rate and disability accumulation. Children with MS have higher relapse rates than adults. Adults with later onset MS have rapid declines in relapse rate over time and faster accumulation of ambulatory disability. Measuring biological age may offer more precision in understanding the role of aging processes in MS pathophysiology. Both somatic and reproductive aging may contribute to disability accumulation. In addition to the effects of normal aging, having MS may lead to accelerated biological age compounding aging-related injury. Age should be considered in therapy planning, taking into account higher relapse rates in youth, lowering relapse rate with aging, and increasing infectious risks with immunosenescence. Lastly, targeting biological aging pathways, including employment of senomorphic and senolytic agents, may be an important future strategy to prevent or treat progressive MS. Level of Information: Basic, Intermediate, Advanced
CATEGORY:
MS Management | Lecture
LEVEL:
Basic, Intermediate, Advanced
CREDIT TYPES AND UNITS:
AAPA: 0.75
ACPE: 0.75
APA: 0.75
AOTA: 0.75
ASWB: 0.75
CME: 0.75
NCPD: 0.75
RD: 0.75